Free-running circadian rhythm of melatonin in a sighted man despite a 24-hour sleep pattern: A non-24-hour circadian syndrome

被引:20
作者
Hashimoto, S [1 ]
Nakamura, K [1 ]
Honma, S [1 ]
Honma, K [1 ]
机构
[1] HOKKAIDO UNIV,SCH MED,DEPT PHYSIOL,SAPPORO,HOKKAIDO 060,JAPAN
关键词
bright light; circadian rhythm; internal desynchronization; melatonin; sleep; social schedule;
D O I
10.1111/j.1440-1819.1997.tb02371.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Sleep and plasma melatonin rhythms were measured longitudinally in a sighted young man (21 years old) under a day-night environment. At each measurement, the responsiveness of the melatonin rhythm to a single light pulse was examined in addition to the 24-hour profile. In experiment 1, the timing of sleep was decided by the subject himself. Although most sleep episodes were observed between 21:02 h and 10:55 h, the plasma melatonin rhythm free-ran for a period of 24.18 h. In experiment 2, the sleep-wake schedule of the subject was strictly fixed. The subject was instructed to go to bed at 24:00 h and wake up, at the latest, before 8:00 h for 40 days. The melatonin rhythm, however, continued to free-run for a period of 24.12 h. Nocturnal melatonin level could not be suppressed by a 3-hour Light pulse of 500 Ix, but was suppressed by a pulse of 1000 Ix. It is concluded that internal desynchronization occurred in this particular sighted subject where the sleep-wake rhythm was entrained by the 24-hour day-night environment, whereas the plasma melatonin rhythm free ran, and that a forced sleep schedule did not act as a strong zeitgeber.
引用
收藏
页码:109 / 114
页数:6
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