Microglia autophagy in ischemic stroke: A double-edged sword

被引：51

作者：

Peng, Li ^{[1
,2
,3
]}

Hu, Guangqiang ^{[4
]}

Yao, Qianfang ^{[1
,2
]}

Wu, Jianming ^{[1
,2
]}

He, Ziyang ^{[1
,2
]}

Law, Betty Yuen-Kwan ^{[5
]}

Hu, Guishan ^{[1
,2
]}

Zhou, Xiaogang ^{[1
,2
]}

Du, Junrong ^{[6
]}

Wu, Anguo ^{[1
,2
]}

Yu, Lu ^{[1
,2
,3
,7
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Sichuan Key Med Lab New Drug Discovery & Druggabil, Luzhou, Peoples R China

[2] Southwest Med Univ, Sch Pharm, Luzhou Key Lab Act Screening & Druggabil Evaluat C, Luzhou, Peoples R China

[3] Southwest Med Univ, Sch Clin Med, Dept Med Imaging, Luzhou, Peoples R China

[4] Southwest Med Univ, Sch Basic Med Sci, Dept Anat, Luzhou, Peoples R China

[5] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[6] Sichuan Univ, West China Sch Pharm, Dept Pharmacol, Minist Educ,Key Lab Drug Targeting & Drug Delivery, Chengdu, Peoples R China

[7] Southwest Med Univ, Sch Basic Med Sci, Dept Chem, Luzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

ischemic stroke; microglia; autophagy; neuroinflammation; therapy; BLOOD-BRAIN-BARRIER; POTENTIAL THERAPEUTIC TARGET; CENTRAL-NERVOUS-SYSTEM; CEREBRAL-ISCHEMIA; NEUROINFLAMMATION; INJURY; ACTIVATION; DISEASE; HEALTH; AMPK;

D O I：

10.3389/fimmu.2022.1013311

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing neurological morbidity and mortality worldwide. In the pathophysiological process of IS, microglia play a beneficial role in tissue repair. However, it could also cause cellular damage, consequently leading to cell death. Inflammation is characterized by the activation of microglia, and increasing evidence showed that autophagy interacts with inflammation through regulating correlative mediators and signaling pathways. In this paper, we summarized the beneficial and harmful effects of microglia in IS. In addition, we discussed the interplay between microglia autophagy and ischemic inflammation, as along with its application in the treatment of IS. We believe this could help to provide the theoretical references for further study into IS and treatments in the future.

引用

页数：18

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