Expression of CD26/dipeptidyl peptidase IV in adult T cell leukemia/lymphoma (ATLL)

被引：19

作者：

Kondo, S

Kotani, T

Tamura, K

Aratake, Y

Uno, H

Tsubouchi, H

Inoue, S

Niho, Y

Ohtaki, S

机构：

[1] MIYAZAKI MED COLL, DEPT LAB MED, MIYAZAKI 88916, JAPAN

[2] MIYAZAKI MED COLL, DIV BLOOD TRANSFUS, MIYAZAKI 88916, JAPAN

[3] MIYAZAKI MED COLL, CENT LAB CLIN INVEST, MIYAZAKI 88916, JAPAN

[4] MIYAZAKI PREFECTURAL HOSP, MIYAZAKI, JAPAN

[5] MIYAZAKI MED COLL, DEPT DERMATOL, MIYAZAKI 88916, JAPAN

[6] KYUSHU UNIV, FAC MED, DEPT INTERNAL MED 1, FUKUOKA 812, JAPAN

来源：

LEUKEMIA RESEARCH | 1996年 / 20卷 / 04期

关键词：

ATLL; CD26; HTLV-I;

D O I：

10.1016/0145-2126(95)00159-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The association of CD26/dipeptidyl peptidase IV (DPPIV) and human T lymphotropic virus type I (HTLV-I) was studied by two approaches. First, we examined the expression of CD26 in peripheral blood mononuclear cells (PBMC) from the patients with adult T cell leukemia/lymphoma (ATLL), an HTLV-I-related malignancy. The expression of CD26 on the surface of PBMC was decreased in all 20 patients with ATLL compared with those from normal individuals (P<0.01) and the expression of the CD26 gene transcript was not detectable in seven out of eight patients with ATLL. Then we compared the quantity of viral DNA in CD26-negative (CD26-) and CD26-positive (CD26+) cells obtained from 17 HTLV-I healthy carriers by using a polymerase chain reaction method. The CD26- cells had a higher copy number of viral DNA than CD26+ cells. These findings indicate that HTLV-I has in vivo tropism to CD26- cells, suggesting that some phenotypes of ATLL cells reflect the in vivo cellular tropism of HTLV-I. (C) 1996 Published by Elsevier Science Ltd.

引用

页码：357 / 363

页数：7

共 35 条

[1]

BLAZQUEZ MV, 1992, J IMMUNOL, V149, P3073

[2]

BRODER CC, 1994, SCIENCE, V264, P1156, DOI 10.1126/science.7909959

[3] T-CELL ACTIVATION ANTIGEN, CD26, AS A COFACTOR FOR ENTRY OF HIV IN CD4+ CELLS [J].