Synthesis and evaluation of anti-proliferative activity of 1,4-disubstituted phthalazines

被引：8
|
作者：
Abouzid, Khaled A. M. [1 ]
Khalil, Nadia A. [2 ]
Ahmed, Eman M. [2 ]
机构：
[1] Ain Shams Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo 11566, Egypt
[2] Cairo Univ, Fac Pharm, Dept Organ Chem, Cairo, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 10期
关键词：
Breast cancer; Anti-proliferative activity; Phthalazine; Phthalazinone; KINASE INHIBITOR; BREAST-CANCER; AGENTS; ANTAGONISTS;
D O I：
10.1007/s00044-011-9874-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new phthalazine derivatives 3a-i and 4a-c were synthesized via the reaction of 1-chlorophthalazine derivative 2 with either N-substituted-piperazines, primary or their secondary amines. The structure of the synthesized, new compounds were characterized by spectral data. The anti-proliferative activity on human breast cancer cell line MCF-7 of the synthesized compounds was determined. The results showed that six of the test compounds (3a, 3g, 3i, and 4a-c) displayed potent cytotoxic activity ranging from 1.4 to 2.3 mu mol.
引用
收藏
页码：3288 / 3293
页数：6
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