Real-Time Clinical Monitoring of Biomolecules

被引：35

作者：

Rogers, Michelle L. ^{[1
]}

Boutelle, Martyn G. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Bioengn, London SW7 2AZ, England

来源：

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 6 | 2013年 / 6卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

microdialysis; biosensor; human; brain; tissue; electrode; SURFACE-PLASMON RESONANCE; RAPID SAMPLING MICRODIALYSIS; ELECTROCHEMICAL GLUCOSE SENSORS; IN-VIVO; DYNAMIC CHANGES; QUANTUM DOTS; ULTRASLOW MICRODIALYSIS; INFLAMMATORY CYTOKINES; MAGNETIC NANOPARTICLES; ONLINE MICRODIALYSIS;

D O I：

10.1146/annurev.anchem.111808.073648

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Continuous monitoring of clinical biomarkers offers the exciting possibility of new therapies that use biomarker levels to guide treatment in real time. This review explores recent progress toward this goal. We initially consider measurements in body fluids by a range of analytical methods. We then discuss direct tissue measurements performed by implanted sensors; sampling techniques, including microdialysis and ultrafiltration; and noninvasive methods. A future directions section considers analytical methods at the cusp of clinical use.

引用

页码：427 / 453

页数：27

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