Potential pitfalls in LC-MS/MS quantification of colistin for therapeutic drug monitoring of patients treated with colistimethate

被引：14

作者：

Barco, Sebastiano ^{[1
]}

Castagnola, Elio ^{[2
]}

Mesini, Alessio ^{[2
]}

Tripodi, Gino ^{[1
]}

Cangemi, Giuliana ^{[1
]}

机构：

[1] IRCCS, Ist Giannina Gaslini, Cent Lab Analyses, Genoa, Italy

[2] IRCCS, Ist Giannina Gaslini, Infect Dis Unit, Genoa, Italy

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2019年 / 170卷

关键词：

Colistin; Colistimethate; LC-MS/MS; Therapeutic drug monitoring; Pitfalls; INFECTION; CHILDREN; PLASMA;

D O I：

10.1016/j.jpba.2019.03.023

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Starting from a warning of possible artificially high plasma colistin concentrations observed in clinical samples in our recently published LC-MS/MS method, we reviewed our analytical assay and demonstrated, for the first time, that caution must be paid to ionization conditions employed in the MS system. The artefact reported here demonstrates that additional experiments should be performed in the course of validation of LC-MS/MS methods to be used in samples containing both colistin and colistimethate. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：193 / 195

页数：3

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