Pluripotent Stem Cell-Derived Hepatocytes: Potential and Challenges in Pharmacology

被引：36

作者：

Szkolnicka, Dagmara ^{[1
]}

Zhou, Wenli ^{[1
]}

Lucendo-Villarin, Balta ^{[1
]}

Hay, David C. ^{[1
]}

机构：

[1] Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 | 2013年 / 53卷

基金：

英国医学研究理事会;

关键词：

human embryonic stem cell; induced pluripotent stem cell; cytochrome p450 metabolism; drug-induced liver injury; genetics; TERM SELF-RENEWAL; IN-VITRO; EFFICIENT DIFFERENTIATION; HEPATOCELLULAR-CARCINOMA; DIRECTED DIFFERENTIATION; HEPATIC DIFFERENTIATION; HUMAN BLASTOCYSTS; PATHWAY ANALYSIS; DRUG-METABOLISM; DEFINED FACTORS;

D O I：

10.1146/annurev-pharmtox-011112-140306

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The liver is a fascinating organ and performs a wide range of functions necessary for life. Because the hepatocyte is the major functional cell type found in the liver, it is important that we better understand its role in health and disease. Functional hepatocytes have been derived from many sources, including human stem cell populations. These models offer new opportunities to further our understanding of human liver biology from diverse genotypes and, in the future, to facilitate the development of novel medicines or cell-based therapies. This review discusses limitations in current cell-based models and the advantages offered by pluripotent stem cell-derived hepatocytes.

引用

页码：147 / 159

页数：13

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