One-step fabrication of poly(o-aminophenol)/multi-walled carbon nanotubes composite film modified electrode and its application for levofloxacin determination in pharmaceuticals

被引：64

作者：

Wen, Wei ^{[1
,2
]}

Zhao, Dong-Ming ^{[2
]}

Zhang, Xiu-Hua ^{[2
]}

Xiong, Hua-Yu ^{[2
]}

Wang, Sheng-Fu ^{[2
]}

Chen, Wei ^{[1
]}

Zhao, Yuan-Di ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Biomed Engn, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Hubei, Peoples R China

[2] Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2012年 / 174卷

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

Levofloxacin; o-Aminophenol; MWCNTs; Electropolymerization; Determination; STRIPPING VOLTAMMETRY; HUMAN URINE; BEHAVIOR; ANTIBIOTICS; CIPROFLOXACIN; NORFLOXACIN; EXTRACTION; DISPERSION; OFLOXACIN; EGGS;

D O I：

10.1016/j.snb.2012.08.010

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, one-step electrochemical polymerized method for the fabrication of poly(o-aminophenol)/multi-walled carbon nanotubes (PoAP/MWCNTs) composite film was developed for the quantitative determination of levofloxacin. Scanning electron microscopy and electrochemical methods were used to characterize the PoAP/MWCNTs nanocomposite film. The sensor fabricated from the nanocomposite film showed good stability and enhanced electrocatalytic ability for the detection of levofloxacin. The large current response of levofloxacin on PoAP/MWCNTs composite film-modified electrode could be ascribed to the synergistic effect of the electrocatalytic property of PoAP and MWCNTs. The oxidative peak current increased linearly with the concentration of levofloxacin in the range of 3.0-200 mu M by differential pulse voltammetry, and the detection limit was 1.0 mu M (S/N = 3). The proposed modified electrode also can be successfully applied to the determination of levofloxacin hydrochloride in pharmaceutical formulations. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：202 / 209

页数：8

共 38 条

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