Effect of amine and carboxyl functionalization of sub-micrometric MCM-41 spheres on controlled release of cisplatin

被引：33
作者：
Arean, C. O. [1 ]
Vesga, M. J. [1 ]
Parra, J. B. [2 ]
Delgado, M. R. [1 ]
机构：
[1] Univ Balearic Isl, Dept Chem, Palma de Mallorca 07122, Spain
[2] CSIC, Inst Nacl Carbon, E-33080 Oviedo, Spain
来源：
CERAMICS INTERNATIONAL | 2013年 / 39卷 / 07期
关键词：
Drug delivery; Cisplatin; MCM-41; Mesoporous materials; MESOPOROUS SILICA NANOPARTICLES; CONTROLLED DRUG-DELIVERY; X-RAY-DIFFRACTION; NITROGEN ADSORPTION; CERVICAL-CANCER; OVARIAN-CANCER; IN-VITRO; CARRIERS; HYDROXYAPATITE; SYSTEM;
D O I：
10.1016/j.ceramint.2013.02.084
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Mesoporous MCM-41 type silica spheres having a sub-micrometer size were synthesized following an adaptation of Stober's method. This parent material was then functionalized with 3-aminopropyl triethoxysilane and with 3-propanonitrile triethoxysilane, followed by oxidation of the cyano-group to the corresponding carboxy-group. After proper characterization, the samples were loaded with cisplatin and subjected to in vitro tests in order to obtain the corresponding drug release profile. The carboxy-functionalized MCM-41 sample was found to show a release kinetics that should facilitate controlled drug delivery over a significantly larger time period (about 140 h) than both, unmodified MCM-41 and amino-functionalized MCM-41 samples. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
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收藏
页码：7407 / 7414
页数：8
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