Modification of hypothalamic-pituitary-adrenocortical activity by serotonergic agents in the rat

被引：0

作者：

Matheson, GK

Knowles, A

Gage, D

Michel, C

Guthrie, D

Bauer, C

Blackbourne, J

Weinzapfel, D

机构：

来源：

PHARMACOLOGY | 1997年 / 55卷 / 02期

关键词：

serotonin; corticosterone; stress; anxiolytics; dexamethasone; tandospirone; enciprazine; carvotroline; gepirone; buspirone; hypothalamic-pituitary-adrenocortical activity;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of tandospirone, enciprazine, gepirone, buspirone (5-HT1A agents) and carvotroline (5-HT2) on hypothalamic-pituitary-adrenocortical activity (HPA) activity were studied. These drugs increased the plasma corticosterone levels in a dose-dependent manner. Their ED50 values were 3.8, 31.8, 3.1, 3.4 and 7.0 mg/kg, respectively. Drug effects peaked between 30 min and 1 h, and plasma corticosterone levels returned to control levels after 2 h. When the drugs were given in conjunction with a rotatory stress, gepirone and enciprazine increased and carvotroline decreased plasma corticosterone levels. Dexamethasone (0.1 mg/kg) pretreatment reduced drug-activated HPA axis activity.

引用

页码：59 / 65

页数：7

共 30 条

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