The effect of oleuropein on apoptotic pathway regulators in breast cancer cells

被引:43
作者
Asgharzade, Samira [1 ]
Sheikhshabani, Somayeh Hashemi [2 ]
Ghasempour, Elham [1 ]
Heidari, Razieh [3 ]
Rahmati, Shima [4 ]
Mohammadi, Mahsa [5 ,6 ]
Jazaeri, Ali [7 ]
Amini-Farsani, Zeinab [1 ,8 ]
机构
[1] Shahrekord Univ Med Sci, Cellular & Mol Res Ctr, Basic Hlth Sci Inst, Shahrekord, Iran
[2] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran
[3] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Med Biotechnol, Shahrekord, Iran
[4] Kurdistan Univ Med Sci, Student Res Comm, Sanandaj, Iran
[5] Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Stem Cells & Dev Biol, ACECR, Tehran, Iran
[6] Univ Sci & Culture, Dept Dev Biol, Tehran, Iran
[7] Shiraz Univ, Coll Sci, Dept Biol, Shiraz, Iran
[8] Univ Sistan & Baluchestan, Dept Biol, Zahedan, Iran
关键词
Oleuropein; MicroRNA; Apoptosis; Breast cancer; CISPLATIN; MICRORNAS; THERAPY; GENES;
D O I
10.1016/j.ejphar.2020.173509
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In spite of advancements in breast cancer therapy, this disease is still one of the significant causes of women fatalities globally. Dysregulation of miRNA plays a pivotal role in the initiation and progression of cancer. Therefore, the administration of herbal compounds with anticancer effects through controlling microRNA expression can be considered as a promising therapy for cancer. Oleumpein is the most prevalent phenolic compound in olive. Given its domestic consumption, low cost, and nontoxicity for human beings, oleumpein can be used in combination with the standard chemotherapy drugs. To this end, we examined the effect of oleuropein on two breast cancer cell lines (MCF7 and MDA-MB-231). Our findings revealed that oleuropein significantly decreased cell viability in a dose- and time-dependent manner, while it increased the apoptosis in MCF7 and MDA-MB-231 cells. In the presence of oleuropein, the expression levels of miR-125b, miR-16, miR-34a, p53, p21, and TNERS10B increased, while that of bcl-2, men, miR-221, miR-29a and miR-21 decreased. The findings pointed out that oeluropein may induce apoptosis via not only increasing the expression of pro-apoptotic genes and tumor suppressor miRNAs, but also decreasing the expression of anti-apoptotic genes and oncomiR. Consequently, oleumpein can be regarded as a suitable herbal medication for cancer therapy.
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页数:9
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