Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions

被引：0
|
作者：
Ostrem, Jonathan M. [1 ]
Peters, Ulf [1 ]
Sos, Martin L. [1 ]
Wells, James A. [2 ]
Shokat, Kevan M. [1 ]
机构：
[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA USA
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
来源：
MOLECULAR CANCER THERAPEUTICS | 2013年 / 12卷 / 11期
关键词：
D O I：
10.1158/1535-7163.TARG-13-PL04-03
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PL04-03
引用
收藏
页数：1
相关论文
共 50 条
  • [1] K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
    Ostrem, Jonathan M.
    Peters, Ulf
    Sos, Martin L.
    Wells, James A.
    Shokat, Kevan M.
    NATURE, 2013, 503 (7477) : 548 - +
  • [2] K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
    Jonathan M. Ostrem
    Ulf Peters
    Martin L. Sos
    James A. Wells
    Kevan M. Shokat
    Nature, 2013, 503 : 548 - 551
  • [3] Optical Control of the GTP Affinity of K-Ras(G12C) by a Photoswitchable Inhibitor
    Ge, Zhihua
    Yang, Zhuojin
    Liang, Jingshi
    Dong, Duoling
    Zhu, Mingyan
    CHEMBIOCHEM, 2019, 20 (23) : 2916 - 2920
  • [4] Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles
    Yu, Zhongtang
    He, Xiaoqiang
    Wang, Ruiliu
    Xu, Xinxin
    Zhang, Zhang
    Ding, Ke
    Zhang, Zhi-Min
    Tan, Yi
    Li, Zhengqiu
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 145 (37) : 20403 - 20411
  • [5] Crystal structure of K-Ras G12C bound to an active site inhibitor
    Hunter, John
    Lim, Sang Min
    Ficcarro, Scott B.
    Choi, Hwan Geun
    Gurbani, Deepak
    Xie, Ting
    Marto, Jarrod A.
    Gray, Nathanael S.
    Westover, Ken
    MOLECULAR CANCER RESEARCH, 2014, 12
  • [6] Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
    Jones, S
    Lambert, S
    Williams, GT
    Best, JM
    Sampson, JR
    Cheadle, JP
    BRITISH JOURNAL OF CANCER, 2004, 90 (08) : 1591 - 1593
  • [7] Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
    S Jones
    S Lambert
    G T Williams
    J M Best
    J R Sampson
    J P Cheadle
    British Journal of Cancer, 2004, 90 : 1591 - 1593
  • [8] Identification of novel K-Ras G12C inhibitors using a DNA encoded library platform
    Arora, Shilpi
    Hupp, Chris
    Talcott, Sarah
    Narayanan, Usha
    Gikunju, Diana
    Von Rechenberg, Mortiz
    Monteiro, Michael I.
    Giulinger, John P.
    Denton, Kyle
    Clark, Matt
    Ferguson, Andrew
    McRiner, Andrew J.
    Cuozzo, John
    Huguet, Christelle
    Keefe, Anthony D.
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (12)
  • [9] Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange
    Nnadi, Chimno I.
    Jenkins, Meredith L.
    Gentile, Daniel R.
    Bateman, Leslie A.
    Zaidman, Daniel
    Balius, Trent E.
    Nomura, Daniel K.
    Burke, John E.
    Shokat, Kevan M.
    London, Nir
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 58 (02) : 464 - 471
  • [10] Prognosis-relevant Factors of K-RAS G12C Lung Cancer Patients for Treatment Decisions
    Kurz, S.
    Lueders, H.
    Grohe, C.
    Angotti, M.
    PNEUMOLOGIE, 2024, 78 : S103 - S103
12345