Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO

被引：92
作者：
Lombel, Rebecca M. [1 ,5 ]
Hodson, Elisabeth M. [2 ,3 ]
Gipson, Debbie S. [1 ,4 ]
机构：
[1] Univ Michigan, Div Nephrol, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA
[2] Childrens Hosp Westmead, Ctr Kidney Res, Sydney, NSW, Australia
[3] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia
[4] Univ Michigan, Michigan Inst Clin & Hlth Res, Ann Arbor, MI 48109 USA
[5] CS Mott Childrens Hosp, Ann Arbor, MI 48109 USA
来源：
PEDIATRIC NEPHROLOGY | 2013年 / 28卷 / 03期
关键词：
Clinical practice guidelines; Steroid-resistant nephrotic syndrome; Children; Management; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; KIDNEY-DISEASE; NPHS2; PODOCIN; CYCLOSPORINE; MUTATIONS; TRIAL; RITUXIMAB; EFFICACY; SAFETY; TIME;
D O I：
10.1007/s00467-012-2304-8
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Kidney Disease: Improving Global Outcomes (KDIGO) recently published the clinical practice guideline on glomerulonephritis (GN) to assist the practitioner caring for patients with GN. Chapter 4 of the guideline focuses on managing children aged 1-18 years with steroid-resistant nephrotic syndrome (SRNS), defined by an inability to achieve complete remission with corticosteroid therapy. Guideline development followed a thorough evidence review, and management recommendations and suggestions were based on the best available evidence. Limitations of the evidence, including the paucity of large-scale randomized controlled trials, are discussed. This article provides both the guideline recommendations and a brief review of relevant treatment trials related to each recommendation. This pr,cis serves as a summary of the complete guidelines recently published.
引用
收藏
页码：409 / 414
页数：6
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