Common variation at 2q22.3 (ZEB2) influences the risk of renal cancer

被引：45

作者：

Henrion, Marc ^{[1
]}

Frampton, Matthew ^{[1
]}

Scelo, Ghislaine ^{[2
]}

Purdue, Mark ^{[3
]}

Ye, Yuanqing ^{[4
]}

Broderick, Peter ^{[1
]}

Ritchie, Alastair ^{[5
]}

Kaplan, Richard ^{[5
]}

Meade, Angela ^{[5
]}

McKay, James ^{[2
]}

Johansson, Mattias ^{[2
]}

Lathrop, Mark ^{[6
]}

Larkin, James ^{[7
]}

Rothman, Nathaniel ^{[3
]}

Wang, Zhaoming ^{[3
,8
]}

Chow, Wong-Ho ^{[3
,4
]}

Stevens, Victoria L. ^{[9
]}

Diver, W. Ryan ^{[9
]}

Gapstur, Susan M. ^{[9
]}

Albanes, Demetrius ^{[3
]}

Virtamo, Jarmo ^{[10
]}

Wu, Xifeng ^{[4
]}

Brennan, Paul ^{[2
]}

Chanock, Stephen ^{[3
]}

Eisen, Timothy ^{[11
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Div Genet & Epidemiol, Sutton SM2 5NG, Surrey, England

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA

[4] Univ Texas MD Anderson Canc Ctr, Div Canc Prevent & Populat Sci, Dept Epidemiol, Houston, TX 77030 USA

[5] MRC Clin Trials Unit, London WC2B 6NH, England

[6] Commissariat Energie Atom, Inst Genom, Ctr Natl Genotypage, F-91000 Evry, France

[7] Royal Marsden NHS Fdn Trust, London, England

[8] NCI, Core Genotyping Facil, SAIC Frederick Inc, Frederick, MD 21701 USA

[9] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[10] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, FIN-00300 Helsinki, Finland

[11] Cambridge Univ Hlth Partners, Cambridge, England

来源：

HUMAN MOLECULAR GENETICS | 2013年 / 22卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; CELL CARCINOMA; SUSCEPTIBILITY LOCI; KIDNEY CANCER; DISEASE; COMPLEX; 2P21;

D O I：

10.1093/hmg/dds489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-wide association studies (GWASs) of renal cell cancer (RCC) have identified four susceptibility loci thus far. To identify an additional RCC common susceptibility locus, we conducted a GWAS and performed a meta-analysis with published GWASs (totalling 2215 cases and 8566 controls of European background) and followed up the most significant association signals [nine single nucleotide polymorphisms (SNPs) in eight genomic regions] in 3739 cases and 8786 controls. A combined analysis identified a novel susceptibility locus mapping to 2q22.3 marked by rs12105918 (P 1.80 10(8); odds ratio 1.29, 95 CI: 1.181.41). The signal localizes to intron 2 of the ZEB2 gene (zinc finger E box-binding homeobox 2). Our findings suggest that genetic variation in ZEB2 influences the risk of RCC. This finding provides further insights into the genetic and biological basis of inherited genetic susceptibility to RCC.

引用

页码：825 / 831

页数：7

共 24 条

[1] Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
Broderick, Peter
Chubb, Daniel
Johnson, David C.
Weinhold, Niels
Foersti, Asta
Lloyd, Amy
Olver, Bianca
Ma, Yussanne P.
Dobbins, Sara E.
Walker, Brian A.
Davies, Faith E.
Gregory, Walter A.
Child, J. Anthony
Ross, Fiona M.
Jackson, Graham H.
Neben, Kai
Jauch, Anna
Hoffmann, Per
Muehleisen, Thomas W.
Noethen, Markus M.
Moebus, Susanne
Tomlinson, Ian P.
Goldschmidt, Hartmut
Hemminki, Kari
Morgan, Gareth J.
Houlston, Richard S.
[J]. NATURE GENETICS, 2012, 44 (01) : 58 - U83
[2] Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study
Broderick, Peter
Wang, Yufei
Vijayakrishnan, Jayaram
Matakidou, Athena
Spitz, Margaret R.
Eisen, Timothy
Amos, Christopher I.
Houlston, Richard S.
[J]. CANCER RESEARCH, 2009, 69 (16) : 6633 - 6641
[3] Epidemiology and risk factors for kidney cancer
Chow, Wong-Ho
Dong, Linda M.
Devesa, Susan S.
[J]. NATURE REVIEWS UROLOGY, 2010, 7 (05) : 245 - 257
[4] Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner
Dimas, Antigone S.
Deutsch, Samuel
Stranger, Barbara E.
Montgomery, Stephen B.
Borel, Christelle
Attar-Cohen, Homa
Ingle, Catherine
Beazley, Claude
Arcelus, Maria Gutierrez
Sekowska, Magdalena
Gagnebin, Marilyne
Nisbett, James
Deloukas, Panos
Dermitzakis, Emmanouil T.
Antonarakis, Stylianos E.
[J]. SCIENCE, 2009, 325 (5945) : 1246 - 1250
[5] Common variation at 10p12.31 near MLLT10 influences meningioma risk
Dobbins, Sara E.
Broderick, Peter
Melin, Beatrice
Feychting, Maria
Johansen, Christoffer
Andersson, Ulrika
Brannstrom, Thomas
Schramm, Johannes
Olver, Bianca
Lloyd, Amy
Ma, Yussanne P.
Hosking, Fay J.
Lonn, Stefan
Ahlbom, Anders
Henriksson, Roger
Schoemaker, Minouk J.
Hepworth, Sarah J.
Hoffmann, Per
Muehleisen, Thomas W.
Noethen, Markus M.
Moebus, Susanne
Eisele, Lewin
Kosteljanetz, Michael
Muir, Kenneth
Swerdlow, Anthony
Simon, Matthias
Houlston, Richard S.
[J]. NATURE GENETICS, 2011, 43 (09) : 825 - 827
[6] Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
Dunlop, Malcolm G.
Dobbins, Sara E.
Farrington, Susan Mary
Jones, Angela M.
Palles, Claire
Whiffin, Nicola
Tenesa, Albert
Spain, Sarah
Broderick, Peter
Ooi, Li-Yin
Domingo, Enric
Smillie, Claire
Henrion, Marc
Frampton, Matthew
Martin, Lynn
Grimes, Graeme
Gorman, Maggie
Semple, Colin
Ma, Yusanne P.
Barclay, Ella
Prendergast, James
Cazier, Jean-Baptiste
Olver, Bianca
Penegar, Steven
Lubbe, Steven
Chander, Ian
Carvajal-Carmona, Luis G.
Ballereau, Stephane
Lloyd, Amy
Vijayakrishnan, Jayaram
Zgaga, Lina
Rudan, Igor
Theodoratou, Evropi
Starr, John M.
Deary, Ian
Kirac, Iva
Kovacevic, Dujo
Aaltonen, Lauri A.
Renkonen-Sinisalo, Laura
Mecklin, Jukka-Pekka
Matsuda, Koichi
Nakamura, Yusuke
Okada, Yukinori
Gallinger, Steven
Duggan, David J.
Conti, David
Newcomb, Polly
Hopper, John
Jenkins, Mark A.
Schumacher, Fredrick
[J]. NATURE GENETICS, 2012, 44 (07) : 770 - U197
[7] A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
Enciso-Mora, Victor
Broderick, Peter
Ma, Yussanne
Jarrett, Ruth F.
Hjalgrim, Henrik
Hemminki, Kari
van den Berg, Anke
Olver, Bianca
Lloyd, Amy
Dobbins, Sara E.
Lightfoot, Tracy
van Leeuwen, Flora E.
Foersti, Asta
Diepstra, Arjan
Broeks, Annegien
Vijayakrishnan, Jayaram
Shield, Lesley
Lake, Annette
Montgomery, Dorothy
Roman, Eve
Engert, Andreas
von Strandmann, Elke Pogge
Reiners, Katrin S.
Nolte, Ilja M.
Smedby, Karin E.
Adami, Hans-Olov
Russell, Nicola S.
Glimelius, Bengt
Hamilton-Dutoit, Stephen
de Bruin, Marieke
Ryder, Lars P.
Molin, Daniel
Sorensen, Karina Meden
Chang, Ellen T.
Taylor, Malcolm
Cooke, Rosie
Hofstra, Robert
Westers, Helga
van Wezel, Tom
van Eijk, Ronald
Ashworth, Alan
Rostgaard, Klaus
Melbye, Mads
Swerdlow, Anthony J.
Houlston, Richard S.
[J]. NATURE GENETICS, 2010, 42 (12) : 1126 - +
[8] Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, Jacques
Shin, Hai-Rim
Bray, Freddie
Forman, David
Mathers, Colin
Parkin, Donald Maxwell
[J]. INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (12) : 2893 - 2917
[9] The structure of haplotype blocks in the human genome
Gabriel, SB
Schaffner, SF
Nguyen, H
Moore, JM
Roy, J
Blumenstiel, B
Higgins, J
DeFelice, M
Lochner, A
Faggart, M
Liu-Cordero, SN
Rotimi, C
Adeyemo, A
Cooper, R
Ward, R
Lander, ES
Daly, MJ
Altshuler, D
[J]. SCIENCE, 2002, 296 (5576) : 2225 - 2229
[10] SYSTEMATIC POPULATION-BASED ASSESSMENT OF CANCER RISK IN FIRST-DEGREE RELATIVES OF CANCER PROBANDS
GOLDGAR, DE
EASTON, DF
CANNONALBRIGHT, LA
SKOLNICK, MH
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (21) : 1600 - 1608

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