Role of Antioxidants and Natural Products in Inflammation

被引：751

作者：

Arulselvan, Palanisamy ^{[1
]}

Fard, Masoumeh Tangestani ^{[2
]}

Tan, Woan Sean ^{[1
]}

Gothai, Sivapragasam ^{[1
]}

Fakurazi, Sharida ^{[1
]}

Norhaizan, Mohd Esa ^{[3
]}

Kumar, S. Suresh ^{[4
]}

机构：

[1] Univ Putra Malaysia, Inst Biosci, Lab Vaccines & Immunotherapeut, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang 43400, Selangor, Malaysia

[3] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia

[4] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Med Microbiol & Parasitol, Serdang 43400, Selangor, Malaysia

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷

关键词：

NF-KAPPA-B; LPS-INDUCED PRODUCTION; INDUCED NITRIC-OXIDE; C-REACTIVE PROTEIN; ANTIINFLAMMATORY ACTIVITIES; IN-VITRO; OXIDATIVE STRESS; MORINGA-OLEIFERA; MYOCARDIAL-ISCHEMIA; LIPID-PEROXIDATION;

D O I：

10.1155/2016/5276130

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Inflammation is a comprehensive array of physiological response to a foreign organism, including human pathogens, dust particles, and viruses. Inflammations are mainly divided into acute and chronic inflammation depending on various inflammatory processes and cellular mechanisms. Recent investigations have clarified that inflammation is a major factor for the progression of various chronic diseases/disorders, including diabetes, cancer, cardiovascular diseases, eye disorders, arthritis, obesity, autoimmune diseases, and inflammatory bowel disease. Free radical productions from different biological and environmental sources are due to an imbalance of natural antioxidants which further leads to various inflammatory associated diseases. In this review article, we have outlined the inflammatory process and its cellular mechanisms involved in the progression of various chronic modern human diseases. In addition, we have discussed the role of free radicals-induced tissue damage, antioxidant defence, and molecular mechanisms in chronic inflammatory diseases/disorders. The systematic knowledge regarding the role of inflammation and its associated adverse effects can provide a clear understanding in the development of innovative therapeutic targets from natural sources that are intended for suppression of various chronic inflammations associated diseases.

引用

页数：15

共 96 条

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