The Role of Vitamin D in Allergic Diseases in Children
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作者:
del Giudice, Michele Miraglia
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Univ Naples 2, Dept Women Child & Gen & Special Surg, Via Crecchio, I-80138 Naples 4, ItalyUniv Naples 2, Dept Women Child & Gen & Special Surg, Via Crecchio, I-80138 Naples 4, Italy
del Giudice, Michele Miraglia
[1
]
Allegorico, Annalisa
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Univ Naples 2, Dept Women Child & Gen & Special Surg, Via Crecchio, I-80138 Naples 4, ItalyUniv Naples 2, Dept Women Child & Gen & Special Surg, Via Crecchio, I-80138 Naples 4, Italy
Allegorico, Annalisa
[1
]
机构:
[1] Univ Naples 2, Dept Women Child & Gen & Special Surg, Via Crecchio, I-80138 Naples 4, Italy
The role of vitamin D in calcium and phosphate homeostasis is well known; however, in addition to traditional functions, vitamin D modulates a variety of processes, and evidence shows that it has an important role in different allergic diseases such as asthma, atopic dermatitis, and food allergy. Vitamin D acts by binding to the vitamin D receptor, which is present in a variety of tissues; for this reason it is considered a hormone. One of the most important functions is to modulate the immune system response, both innate and adaptive, by suppressing Th2-type response and increasing natural killer cells. Recent studies show that higher serum levels of 25-hydroxyvitamin D were associated with a reduced risk for asthma exacerbations and hospitalization. Other experimental data suggest that vitamin D can potentially increase the therapeutic response to glucocorticoid and potentially be used as an add-on treatment in steroid-resistant asthmatic patients. However, vitamin D stimulates the production and regulation of skin antimicrobial peptides, such as cathelicidins, which have both direct antimicrobial activity and induced host cellular response by triggering cytokine release. Recent evidence suggests that low blood vitamin D level is a risk factor for food allergy; vitamin D deficiency predisposes to gastrointestinal infections, which may promote the development of food allergy. In conclusion, several data suggest that serum 25-hydroxyvitamin D levels are often insufficient in children with asthma, atopic dermatitis, and food allergy. Further clinical trials are needed to provide conclusive evidence and to identify the effects of vitamin D in allergic diseases.
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Natl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Miyazaki, Celine
Koyama, Momoko
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Univ Tokyo, Grad Sch Med, Dept Community & Global Hlth, 7-3-1 Hongo, Tokyo 1138654, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Koyama, Momoko
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Ota, Erika
Swa, Toshiyuki
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Natl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Osaka Univ, Grad Sch Human Sci, 1-1 Yamadaoka Suita, Osaka 5650871, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Swa, Toshiyuki
Mlunde, Linda B.
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Univ Tokyo, Grad Sch Med, Dept Community & Global Hlth, 7-3-1 Hongo, Tokyo 1138654, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Mlunde, Linda B.
Amiya, Rachel M.
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Univ Tokyo, Grad Sch Med, Dept Family Nursing, 7-3-1 Hongo, Tokyo 1138654, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Amiya, Rachel M.
Tachibana, Yoshiyuki
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Natl Ctr Child Hlth & Dev, Dept Psychosocial Med, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Tachibana, Yoshiyuki
Yamamoto-Hanada, Kiwako
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Natl Ctr Child Hlth & Dev, Dept Med Specialties, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
Yamamoto-Hanada, Kiwako
Mori, Rintaro
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Natl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, JapanNatl Ctr Child Hlth & Dev, Dept Hlth Policy, Setagaya Ku, 10-1-2 Okura, Tokyo 1578535, Japan
机构:
Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
James, Laura
Majure, Joseph M.
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Univ Mississippi, Dept Pediat, Oxford, MS USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
Majure, Joseph M.
Bickel, Scott
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Univ Louisville, Dept Pediat, Louisville, KY 40292 USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
Bickel, Scott
Ly-Thao Phan
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Nemours Childrens Hlth Syst, Dept Pediat, Wilmington, DE USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
Ly-Thao Phan
Gonzalez, Monica Serrano
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Brown Univ, Dept Pediat, Warren Alpert Med Sch, Providence, RI 02912 USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
Gonzalez, Monica Serrano
Staples, Heather
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Univ South Carolina, Dept Pediat, Columbia, SC 29208 USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
Staples, Heather
Tam-Williams, Jade
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Univ Missouri, Dept Pediat, Sch Med, Kansas City, MO 64110 USA
Childrens Mercy Hosp, Kansas City, MO 64108 USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
Tam-Williams, Jade
Lang, Jason
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Duke Clin Res Inst, Durham, NC USA
Duke Univ, Sch Med, Durham, NC USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
Lang, Jason
Snowden, Jessica
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Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USADartmouth Coll, Dept Pediat, Geisel Sch Med, Hanover, NH 03755 USA
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Zunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R ChinaZunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R China
Liu, Zhu
Huang, Shiming
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Zunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R ChinaZunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R China
Huang, Shiming
Yuan, Xiaoli
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Zunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R ChinaZunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R China
Yuan, Xiaoli
Wang, Yan
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Zunyi Med Univ, Affiliated Hosp, Dept Burn & Plast Surg Ward, Zunyi, Peoples R ChinaZunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R China
Wang, Yan
Liu, Yannan
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Hunan Univ Med, Nursing Sch, Huaihua 418000, Hunan, Peoples R ChinaZunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R China
Liu, Yannan
Zhou, Jing
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Zunyi Med Univ, Affiliated Hosp 2, Dept Nursing, Zunyi, Peoples R China
Zunyi Med Univ, Affiliated Hosp 2, Intersect Xinlong Ave & Xinpu Ave, Zunyi, Guizhou, Peoples R ChinaZunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Peoples R China
机构:
Brigham Young Univ, Dept Psychol, Provo, UT 84602 USARoseman Univ Hlth Sci, Coll Dent Med, 10894 S River Front Pkwy, South Jordan, UT 84095 USA
Birmingham, Wendy C.
Ocampo, Monica
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Roseman Univ Hlth Sci, Coll Dent Med, 10894 S River Front Pkwy, South Jordan, UT 84095 USARoseman Univ Hlth Sci, Coll Dent Med, 10894 S River Front Pkwy, South Jordan, UT 84095 USA
Ocampo, Monica
Mohajeri, Amir
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Roseman Univ Hlth Sci, Coll Dent Med, 10894 S River Front Pkwy, South Jordan, UT 84095 USARoseman Univ Hlth Sci, Coll Dent Med, 10894 S River Front Pkwy, South Jordan, UT 84095 USA