18F-DOPA, a Clinically Available PET Tracer to Study Brain Inflammation?

被引：34

作者：

Sala, Quentin ^{[1
,2
]}

Metellus, Philippe ^{[3
]}

Taieb, David ^{[1
,2
]}

Kaphan, Elsa ^{[4
]}

Figarella-Branger, Dominique ^{[5
]}

Guedj, Eric ^{[1
,2
,6
]}

机构：

[1] Hop Enfants La Timone, APHM, Serv Cent Biophys & Med Nucl, Marseille, France

[2] Aix Marseille Univ, CERIMED, Marseille, France

[3] Hop Enfants La Timone, APHM, Serv Neurochirurg, Marseille, France

[4] Hop Enfants La Timone, APHM, Serv Neurol, Marseille, France

[5] Hop Enfants La Timone, APHM, Serv Anat Pathol & Neuropathol, Marseille, France

[6] Aix Marseille Univ, CNRS, UMR7289, INT, Marseille, France

来源：

CLINICAL NUCLEAR MEDICINE | 2014年 / 39卷 / 04期

关键词：

brain inflammation; FDOPA; sarcoidosis; PET; encephalitis;

D O I：

10.1097/RLU.0000000000000383

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We report 2 cases of suspected low-grade glioma with positive F-18-fluorodihydroxyphenylalanine (F-18-FDOPA) PET scan, and histological diagnosis of brain inflammation corresponding to an acute disseminated encephalomyelitis (ADEM) and to a neurosarcoidosis. It has been shown that this amino-acid PET radiotracer serves to evaluate tumoral proliferation related to the metabolism of l-amino-acid transporters, and that inflammation may also contribute to the tumoral uptake. This report suggests it may serve to study brain inflammation.

引用

页码：E283 / E285

页数：3

共 8 条

[1] Acute Disseminated Encephalomyelitis [J].

Alper, Gulay .

JOURNAL OF CHILD NEUROLOGY, 2012, 27 (11) :1408-1425

[2] L-type amino acid transporters LAT1 and LAT4 in cancer:: Uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo [J].

Haase, Cathleen ;

Bergmann, Ralf ;

Fuechtner, Frank ;

Hoepping, Alexander ;

Pietzsch, Jens .

JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (12) :2063-2071

[3]

Heiss WD, 1996, J NUCL MED, V37, P1180

[4]

Karunanithi S, 2014, CLIN NUCL MED, V39, pE121, DOI 10.1097/RLU.0b013e318279bcd8

[5] F-18 Fluorodeoxyglucose and F-18 Fluorothymidine Positron Emission Tomography/Computed Tomography Imaging in a Case of Neurosarcoidosis [J].

Kim, Seok-Ki ;

Im, Hyung Jun ;

Kim, Woojun ;

Kim, Tae-Sung ;

Hwangbo, Bin ;

Kim, Ho Jin .

CLINICAL NUCLEAR MEDICINE, 2010, 35 (02) :67-70

[6] Evaluation of Quantitative Criteria for Glioma Grading With Static and Dynamic 18F-FDopa PET/CT [J].

Nioche, Christophe ;

Soret, Marine ;

Gontier, Eric ;

Lahutte, Marion ;

Dutertre, Guillaume ;

Dulou, Renaud ;

Capelle, Laurent ;

Guillevin, Remy ;

Foehrenbach, Herve ;

Buvat, Irene .

CLINICAL NUCLEAR MEDICINE, 2013, 38 (02) :81-87

[7] Neurosarcoidosis [J].

Nozaki, Kenkichi ;

Judson, Marc A. .

CURRENT TREATMENT OPTIONS IN NEUROLOGY, 2013, 15 (04) :492-504

[8] Comparative Evaluation of F-18 FDOPA, F-18 FDG, and F-18 FLT-PET/CT for Metabolic Imaging of Low Grade Gliomas [J].

Tripathi, Madhavi ;

Sharma, Rajnish ;

D'Souza, Maria ;

Jaimini, Abhinav ;

Panwar, Puia ;

Varshney, Raunak ;

Datta, Anupama ;

Kumar, Nitin ;

Garg, Gunjan ;

Singh, Dinesh ;

Grover, Rajesh K. ;

Mishra, Anil K. ;

Mondal, Anupam .

CLINICAL NUCLEAR MEDICINE, 2009, 34 (12) :878-883

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