18F-DOPA, a Clinically Available PET Tracer to Study Brain Inflammation?

被引：36

作者：

Sala, Quentin ^{[1
,2
]}

Metellus, Philippe ^{[3
]}

Taieb, David ^{[1
,2
]}

Kaphan, Elsa ^{[4
]}

Figarella-Branger, Dominique ^{[5
]}

Guedj, Eric ^{[1
,2
,6
]}

机构：

[1] Hop Enfants La Timone, APHM, Serv Cent Biophys & Med Nucl, Marseille, France

[2] Aix Marseille Univ, CERIMED, Marseille, France

[3] Hop Enfants La Timone, APHM, Serv Neurochirurg, Marseille, France

[4] Hop Enfants La Timone, APHM, Serv Neurol, Marseille, France

[5] Hop Enfants La Timone, APHM, Serv Anat Pathol & Neuropathol, Marseille, France

[6] Aix Marseille Univ, CNRS, UMR7289, INT, Marseille, France

来源：

CLINICAL NUCLEAR MEDICINE | 2014年 / 39卷 / 04期

关键词：

brain inflammation; FDOPA; sarcoidosis; PET; encephalitis;

D O I：

10.1097/RLU.0000000000000383

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We report 2 cases of suspected low-grade glioma with positive F-18-fluorodihydroxyphenylalanine (F-18-FDOPA) PET scan, and histological diagnosis of brain inflammation corresponding to an acute disseminated encephalomyelitis (ADEM) and to a neurosarcoidosis. It has been shown that this amino-acid PET radiotracer serves to evaluate tumoral proliferation related to the metabolism of l-amino-acid transporters, and that inflammation may also contribute to the tumoral uptake. This report suggests it may serve to study brain inflammation.

引用

页码：E283 / E285

页数：3

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