Synthesis of polyphosphonates containing 5-flouro-N1-furanyl-N3-glyceroalkyl-uracil and formyl groups

被引：0
作者：
Bai, L
Chen, RY
Zhu, YY
机构：
[1] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China
[2] Nankai Univ, Natl Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2002年 / 13卷 / 01期
关键词：
polyphosphates; furanyl; glyceryl; 5-flourouracil; formyl;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel polyphosphonates containing 5-flouro-N-1-furanyl-N-3-glyceroalkyl-uracil and formyl groups was synthesized by the condensation of 3-(omega-(1'-furanyl-5-flourouracil-3-yl) alkoxy)-1, 2-dihydroxy prune with phosphonyl dichloride. The products were characterized by IR, H-1 NMR, P-31 NMR, M,and elemental analysis. The results of bioassay show that compound 8a possesses potential anticancer activity.
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页码：29 / 32
页数：4
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