Synthesis and Properties of Pyridine-4-carboxamide-1,3,4-oxadiazoles

被引：3

作者：

Zheng, Juan ^{[1
]}

Chen, Yu ^{[2
]}

Wu, Kongli ^{[1
]}

Ran, Chunling ^{[1
]}

Xu, Yan ^{[1
]}

Song, Maoping ^{[1
]}

机构：

[1] Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Coll Basic Med, Zhengzhou 450001, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 33卷 / 07期

基金：

中国国家自然科学基金;

关键词：

1,3,4-oxadiazole; fluorescence; biological activity; SULFUR ETHERS; 1,3,4-OXADIAZOLE; ANTIBACTERIAL; LAYER;

D O I：

10.6023/cjoc201301039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new 2,5-disubstituted 1,3,4-oxadiazole derivative N-(5-aromatic-1,3,4-oxadiazol-2-yl)picolinamides 2a similar to 2d were obtained by condensation, oxidization and acylation reactions, with isonicotinic acid and single substituted aromatic aldehydes as raw materials. These compounds were characterized by IR, 1H NMR and elemental analysis. Fluorescence test results indicated that Cu2+ could make this series compounds fluorescence quenching, and Zn2+ could only enhance the fluorescence intensity of N-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]isonicotinamide (2b). Furthermore, those compounds all showed good fungicidal activity against the tested bacteria, and among them, N-(5-p-tolyl-1,3,4-oxadiazol-2-yl)isonicotinamide (2d) against Gibberella zeae was reached 100%.

引用

页码：1536 / 1539

页数：4

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