Observations on the development of congestive heart failure in Irish wolfhounds with dilated cardiomyopathy

被引:39
作者
Brownlie, SE
Cobb, MA
机构
[1] Broadacres, Northampton NN7 1AW, England
[2] Univ London Royal Vet Coll, Dept Small Anim Med & Surg, Hatfield AL9 7TA, Herts, England
关键词
D O I
10.1111/j.1748-5827.1999.tb03102.x
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Records of previous electrocardiographic (ECG) and echocardiographic examinations of 39 Irish wolf hounds with cardiac failure, obtained during a 10-year survey, were examined to establish whether previously detected abnormalities might be prognostic indicators for the development of congestive heart failure (CHF) due to dilated cardiomyopathy (DCM) in later life. Eighteen dogs (46 per cent) had had atrial fibrillation (AF) at their first examination. Other ECG abnormalities detected at previous examinations were ventricular and supraventricular premature contractions, first and second degree atrioventricular block, P mitrale and left anterior fascicular and right bundle branch blocks. All 39 dogs had developed AF by the time of onset of CHF. The mean age at which CHF was diagnosed was 77 months in males and 86 months in females. The mean age at which AF was first detected was 45 months in males and 59 months in females, and the mean time from the first detection of AF to CHF was 27 months in males and 24 months in females. Previous echocardiographic examinations in eight dogs, over a period of up to five years, revealed progressive left atrial and left ventricular dilatation, Fractional shortening was reduced to below the normal range at the onset of CHF compared with previous examinations in three cases but increased in five. It appears, therefore, that certain ECG abnormalities, especially AF, and/or progressive ventricular and atrial dilatation, may be indicators of 'occult' DCM in wolfhounds.
引用
收藏
页码:371 / 377
页数:7
相关论文
共 15 条
[1]   Is atrial fibrillation sometimes a genetic disease? [J].
Allessie, MA .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (13) :950-952
[2]   ARTRIAL FIBRILLATION IN DOGS [J].
BOHN, FK ;
PATTERSON, DF ;
PYLE, RL .
BRITISH VETERINARY JOURNAL, 1971, 127 (10) :485-+
[3]   AN ELECTROCARDIOGRAPHIC SURVEY OF CARDIAC-RHYTHM IN IRISH WOLFHOUNDS [J].
BROWNLIE, SE .
VETERINARY RECORD, 1991, 129 (21) :470-471
[4]  
BROWNLIE SE, 1990, BRIT J RADIOL, V63, P399
[5]   Atrial fibrillation is associated with an increased risk for mortality and heart failure progression in patients with asymptomatic and symptomatic left ventricular systolic dysfunction: A retrospective analysis of the SOLVD trials [J].
Dries, DL ;
Exner, DV ;
Gersh, BJ ;
Domanski, MJ ;
Waclawiw, MA ;
Stevenson, LW .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (03) :695-703
[6]  
FOX PR, 1988, CANINE FELINE CARDIO, P467
[7]   CARDIAC BIOPSY IN PATIENTS WITH PRIMARY ATRIAL-FIBRILLATION - HISTOLOGIC EVIDENCE OF OCCULT MYOCARDIAL DISEASES [J].
FRUSTACI, A ;
CALDARULO, M ;
BUFFON, A ;
BELLOCCI, F ;
FENICI, R ;
MELINA, D .
CHEST, 1991, 100 (02) :303-306
[8]  
HARPSTER NK, 1994, P 12 ACVIM FOR SAN F, P319
[9]   A GENE DEFECT THAT CAUSES CONDUCTION SYSTEM DISEASE AND DILATED CARDIOMYOPATHY MAPS TO CHROMOSOME 1P1-1Q1 [J].
KASS, S ;
MACRAE, C ;
GRABER, HL ;
SPARKS, EA ;
MCNAMARA, D ;
BOUDOULAS, H ;
BASSON, CT ;
BAKER, PB ;
CODY, RJ ;
FISHMAN, MC ;
COX, N ;
KONG, A ;
WOOLEY, CF ;
SEIDMAN, JG ;
SEIDMAN, CE .
NATURE GENETICS, 1994, 7 (04) :546-551
[10]  
O'Grady M R., 1995, Proc 13th ACVIM Forum, P298