Soluble endoglin, hypercholesterolemia and endothelial dysfunction

被引：53
作者：
Rathouska, Jana [1 ]
Jezkova, Katerina [1 ]
Nemeckova, Ivana [1 ]
Nachtigal, Petr [1 ]
机构：
[1] Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Biol & Med Sci, Hradec Kralove 50005, Czech Republic
来源：
ATHEROSCLEROSIS | 2015年 / 243卷 / 02期
关键词：
Soluble endoglin; Hypercholesterolemia; Endothelial dysfunction; GROWTH-FACTOR-BETA; CELL-ADHESION MOLECULES; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; ENOS EXPRESSION; SERUM-LEVELS; CD105; ATHEROSCLEROSIS; RECEPTOR; RELEASE;
D O I：
10.1016/j.atherosclerosis.2015.10.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A soluble form of endoglin (sEng) is known to be an extracellular domain of the full-length membrane endoglin, which is elevated during various pathological conditions related to vascular endothelium. In the current review, we tried to summarize a possible role of soluble endoglin in cardiovascular pathologies, focusing on its relation to endothelial dysfunction and cholesterol levels. We discussed sEng as a proposed biomarker of cardiovascular disease progression, cardiovascular disease treatment and endothelial dysfunction. We also addressed a potential interaction of sEng with TGF-beta/eNOS or BMP-9 signaling. We suggest soluble endoglin levels to be monitored, because they reflect the progression/treatment efficacy of cardiovascular diseases related to endothelial dysfunction and hypercholesterolemia. A possible role of soluble endoglin as an inducer of endothelial dysfunction however remains to be elucidated. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：383 / 388
页数：6
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