A simple and efficient synthesis of isoindolinone derivatives based on reaction of ortho-lithiated aromatic imines with CO

被引：15

作者：

Li, Hai-Jun ^{[1
]}

Zhang, Yu-Qing ^{[1
]}

Tang, Liang-Fu ^{[1
]}

机构：

[1] Nankai Univ, Dept Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

TETRAHEDRON | 2015年 / 71卷 / 40期

基金：

中国国家自然科学基金;

关键词：

Isoindolinone; Aromatic imine; Lithiation; Carbon monoxide; Fungicidal activity; ONE-POT SYNTHESIS; H BOND ACTIVATION; ASYMMETRIC-SYNTHESIS; CARBONYLATIVE CYCLIZATION; CATALYZED CARBONYLATION; FACILE SYNTHESIS; PHTHALIMIDES; ISOINDOLONES; ALDEHYDES; RADICALS;

D O I：

10.1016/j.tet.2015.07.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient one-pot synthesis of 2,3-disubstituted isoindolinones via the reaction of o-lithiated aromatic imines with carbon monoxide under one atmospheric pressure has been developed. Preliminary in vitro tests for fungicidal activity of these isoindolinone derivatives have been carried out, indicating that most of them exhibit good fungicidal activities. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：7681 / 7686

页数：6

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