Pathogenesis of Cryptosporidium parvum infection

被引：62

作者：

Laurent, F ^{[1
]}

McCole, D ^{[1
]}

Eckmann, L ^{[1
]}

Kagnoff, MF ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Lab Mucosal Immunol, La Jolla, CA 92093 USA

来源：

MICROBES AND INFECTION | 1999年 / 1卷 / 02期

关键词：

Cryptosporidium parvum; intestine; epithelial cell; xenograft; chemokine; prostaglandins; cyclooxygenase; AIDS; immune response;

D O I：

10.1016/S1286-4579(99)80005-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptosporidium parvum can be regarded as a minimally invasive mucosal pathogen, since it invades surface epithelial cells that line the intestinal tract but does not invade deeper layers of the intestinal mucosa. Nonetheless, infection can be associated with diarrhea and marked mucosal inflammation. This article briefly reviews in vitro and in vivo models useful for studying the pathogenesis of C. parvum infection and explores the role of innate and acquired immune responses in host defense against this protozoan parasite. (C) Elsevier, Paris.

引用

页码：141 / 148

页数：8

共 59 条

[1] Localization of alpha/beta and gamma/delta T lymphocytes in Cryptosporidium parvum-infected tissues in naive and immune calves [J].

Abrahamsen, MS ;

Lancto, CA ;

Walcheck, B ;

Layton, W ;

Jutila, MA .

INFECTION AND IMMUNITY, 1997, 65 (06) :2428-2433

[2] CRYPTOSPORIDIUM-PARVUM INFECTION OF INTESTINAL EPITHELIUM - MORPHOLOGIC AND FUNCTIONAL-STUDIES IN AN IN-VITRO MODEL [J].

ADAMS, RB ;

GUERRANT, RL ;

ZU, SX ;

FANG, GD ;

ROCHE, JK .

JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (01) :170-177

[3] SUSCEPTIBILITY OF MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I-DEFICIENT AND MHC CLASS II-DEFICIENT MICE TO CRYPTOSPORIDIUM-PARVUM INFECTION [J].

AGUIRRE, SA ;

MASON, PH ;

PERRYMAN, LE .

INFECTION AND IMMUNITY, 1994, 62 (02) :697-699

[4]

[Anonymous], 1997, CRYPTOSPORIDIUM CRYP

[5]

Argenzio RA, 1996, J PHARMACOL EXP THER, V279, P1109

[6] VILLOUS ATROPHY, CRYPT HYPERPLASIA, CELLULAR INFILTRATION, AND IMPAIRED GLUCOSE-NA ABSORPTION IN ENTERIC CRYPTOSPORIDIOSIS OF PIGS [J].

ARGENZIO, RA ;

LIACOS, JA ;

LEVY, ML ;

MEUTEN, DJ ;

LECCE, JG ;

POWELL, DW .

GASTROENTEROLOGY, 1990, 98 (05) :1129-1140

[7] PROSTANOIDS INHIBIT INTESTINAL NACL ABSORPTION IN EXPERIMENTAL PORCINE CRYPTOSPORIDIOSIS [J].

ARGENZIO, RA ;

LECCE, J ;

POWELL, DW .

GASTROENTEROLOGY, 1993, 104 (02) :440-447

[8]

Argenzio RA, 1997, J PHARMACOL EXP THER, V283, P692

[9] INVITRO ACTIVITIES OF LYTIC PEPTIDES AGAINST THE SPOROZOITES OF CRYPTOSPORIDIUM-PARVUM [J].

ARROWOOD, MJ ;

JAYNES, JM ;

HEALEY, MC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (02) :224-227

[10] INEFFICACY OF INTESTINAL SECRETORY IMMUNE-RESPONSE TO CRYPTOSPORIDIUM IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

BENHAMOU, Y ;

KAPEL, N ;

HOANG, C ;

MATTA, H ;

MEILLET, D ;

MAGNE, D ;

RAPHAEL, M ;

GENTILINI, M ;

OPOLON, P ;

GOBERT, JG .

GASTROENTEROLOGY, 1995, 108 (03) :627-635

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