Elimination Half-Lives of Acute Phase Proteins in Rats and Beagle Dogs During Acute Inflammation

被引：9

作者：

Kuribayashi, Takashi ^{[1
]}

Seita, Tetsuro ^{[1
]}

Momotani, Eiichi ^{[2
]}

Yamazaki, Shunsuke ^{[3
]}

Hagimori, Kohei ^{[4
]}

Yamamoto, Shizuo ^{[1
]}

机构：

[1] Azabu Univ, Grad Sch Environm & Hlth Sci, Chou Ku, Sagamihara, Kanagawa 2525201, Japan

[2] Tohto Coll Hlth Sci, Dept Human Hlth Care, Fukaya, Saitama 3660052, Japan

[3] Kamakura Womens Univ, Dept Food & Nutr, Physiol Lab, Kamakura, Kanagawa 2478512, Japan

[4] Azabu Univ, Fac Life & Environm Sci, Immunol Lab, Chou Ku, Sagamihara, Kanagawa 2525201, Japan

来源：

INFLAMMATION | 2015年 / 38卷 / 04期

关键词：

CRP; AAG; alpha; 2M; half-life; beagle dogs; rats; C-REACTIVE PROTEIN; ALPHA-1-ACID GLYCOPROTEIN; ADULT DOGS; SERUM; ALPHA(2)-MACROGLOBULIN; HEALTHY; YOUNG; DAMAGE;

D O I：

10.1007/s10753-015-0114-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The half-lives of typical acute phase proteins in rats and beagle dogs during acute inflammation were investigated. Acute inflammation was induced by injection of turpentine oil in rats and administration of indomethacin in beagle dogs. Serum concentrations of alpha(2)-macroglobulin (alpha 2M) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay and alpha(1)-acid glycoprotein (AAG) was measured by single radial immunodiffusion. Half-life was calculated as 0.693/elimination rate constant (K). The mean half-lives in the terminal elimination phase of alpha 2M and AAG were 68.1 and 164.8 h, respectively. The half-life of AAG was significantly longer than that of alpha 2M. Mean half-lives in the terminal elimination phase of CRP and AAG were 161.9 and 304.4 h, respectively. The half-life of AAG was significantly longer than that of CRP in beagle dogs. No significant differences in the half-life of AAG were observed between rats and beagle dogs. Furthermore, serum concentrations in the terminal elimination phase could be simulated with the K data acquired in this study.

引用

页码：1401 / 1405

页数：5