Enhancement of scaffolding properties for poly(3-hydroxybutyrate): blending with poly-β-alanine and wet electrospinning

被引：7
作者：
Catiker, E. [1 ]
Konuk, E. [2 ]
Gultan, T. [3 ]
Gumusderelioglu, M. [2 ]
机构：
[1] Ordu Univ, Fac Art & Sci, Ordu, Turkey
[2] Hacettepe Univ, Inst Grad Studies Sci, Ankara, Turkey
[3] Atilim Univ, Fac Engn, Ankara, Turkey
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 06期
关键词：
Scaffold; biocompatibility; Poly-beta-alanine; Poly(3-hydroxybutyrate); cell culture; tissue engineering; IN-VIVO DEGRADATION; CRYSTALLIZATION BEHAVIOR; POLY(ETHYLENE GLYCOL); BIODEGRADATION; POLYHYDROXYBUTYRATE; FILMS; ACID;
D O I：
10.1080/00914037.2018.1552862
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Poly-beta-alanine (PBA), and its derivatives poly(alpha-methyl-beta-alanine) and poly[N-(3-methoxypropyl-beta-alanine) were synthesized by hydrogen transfer polymerization (HTP). Porous 3 D matrices of poly(3-hydroxybutyrate) (P3HB) reinforced with PBA/its derivatives were obtained via lyophilization and wet electrospinning. However, mechanical properties of the porous matrices prepared by wet electrospinning were found to present superior performance for tissue engineering applications. Cell culture study was performed by using wet electrospun P3HB matrices doped with 10% (w/w) PBA which show better manipulation ability, chemical and mechanical properties. Scaffolds of P3HB-PBA (10% w/w) blend was determined to demonstrate better cell attachment and proliferation compared to the scaffolds of pure P3HB.
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页码：338 / 349
页数：12
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