Synthesis of photoluminescent carbon dots and its effect on chondrocytes for knee joint therapy applications

被引：16

作者：

Sun, Rui ^{[1
]}

Liu, Shichao ^{[2
]}

机构：

[1] Zhengzhou Univ, Dept Pharm, Luoyang Cent Hosp, Luoyang, Peoples R China

[2] Luoyang Ctr Women & Children Hlth Care, Dept Pharm, Luoyang, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2019年 / 47卷 / 01期

关键词：

CDs; cytotoxicity; chondrocytes; REDUCED GRAPHENE OXIDE; IN-VITRO CYTOTOXICITY; QUANTUM DOTS; SILVER NANOPARTICLES; GREEN SYNTHESIS;

D O I：

10.1080/21691401.2019.1593855

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the process of natural precursors examining for the carbon dots (CDs) synthesis, a bio-friendly and highly luminescent CDs synthesis is being reported herein. For the first time, we are reporting CDs synthesis using Selenicereus grandiflorus plant materials without any use of additional oxidizing agents like ethanol which was used in the earlier mentioned reports. Ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron (HR-TEM) microscopy and Raman spectroscopy. This method is entirely safe to use in all biological practices because no toxic chemicals were used in this method. Further, we studied the toxicity of CDs against chondrocytes obtained from the knee joint. In order to inquire about the feasible harmful effects of exposing CD on the knee cells, we carried out CD treatment in SW-1353 chondrocytes. Cytotoxicity outcomes displayed a dosage-dependent reduction of cell viability. Therefore, we studied the toxic effects of CDs on the knee, indicating the important prospectives of CDs in future knee therapy.

引用

页码：1321 / 1325

页数：5

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