Evaluating tumor-suppressor gene combinations

被引：2
作者：
Kim, James [1 ,2 ,3 ]
Minna, John D. [1 ,2 ,4 ]
机构：
[1] Univ Texas Southwestern, Dept Internal Med, Div Hematol Oncol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[3] Univ Texas Southwestern, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA
[4] Univ Texas Southwestern, Dept Pharmacol, Dallas, TX USA
来源：
NATURE GENETICS | 2018年 / 50卷 / 04期
关键词：
CELL LUNG-CANCER; IN-VIVO; ADENOCARCINOMA; LANDSCAPE;
D O I：
10.1038/s41588-018-0095-y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In vivo verification of tumor suppressors and their interactions with each other has required complex experiments. A report in this issue uses a novel CRISPR-Cas9 technology with barcodes to test, in parallel, the tumorigenic potential of functional loss of multiple tumor-suppressor genes in the context of a genetically engineered mouse model of lung adenocarcinoma with mutant Kras.
引用
收藏
页码：480 / 482
页数：4
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