Evaluating tumor-suppressor gene combinations

被引：2

作者：

Kim, James ^{[1
,2
,3
]}

Minna, John D. ^{[1
,2
,4
]}

机构：

[1] Univ Texas Southwestern, Dept Internal Med, Div Hematol Oncol, Dallas, TX 75390 USA

[2] Univ Texas Southwestern, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA

[3] Univ Texas Southwestern, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA

[4] Univ Texas Southwestern, Dept Pharmacol, Dallas, TX USA

来源：

NATURE GENETICS | 2018年 / 50卷 / 04期

关键词：

CELL LUNG-CANCER; IN-VIVO; ADENOCARCINOMA; LANDSCAPE;

D O I：

10.1038/s41588-018-0095-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In vivo verification of tumor suppressors and their interactions with each other has required complex experiments. A report in this issue uses a novel CRISPR-Cas9 technology with barcodes to test, in parallel, the tumorigenic potential of functional loss of multiple tumor-suppressor genes in the context of a genetically engineered mouse model of lung adenocarcinoma with mutant Kras.

引用

页码：480 / 482

页数：4

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