Genotoxicity and antileishmanial activity evaluation of Physalis angulata concentrated ethanolic extract

被引：27

作者：

Nogueira, Renata Campos ^{[1
]}

Costa Rocha, Vinicius Pinto ^{[1
]}

Nonato, Fabiana Regina ^{[1
]}

Barbosa Tomassini, Therezinha Coelho ^{[2
]}

Ribeiro, Ivone Maria ^{[2
]}

dos Santos, Ricardo Ribeiro ^{[1
]}

Pereira Soares, Milena Botelho ^{[1
]}

机构：

[1] Fundacao Oswald Cruz, Ctr Pesquisas Gongalo Moniz, Salvador, BA, Brazil

[2] Fundacao Oswald Cruz, Rio De Janeiro, RJ, Brazil

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 36卷 / 03期

关键词：

Genotoxicity; Leishmaniasis; Physalis angulata L; Ames test; Micronucleus test; IN-VITRO; LEISHMANIASIS; L; SOLANACEAE;

D O I：

10.1016/j.etap.2013.10.013

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Antileishmanial in vitro tests, as well as Ames and micronucleus assays were performed with a concentrated ethanolic extract of Physalis angulata (EEPA) Results: EEPA did not present mutagenic effect in Salmonella typhimurium strains at concentration reaching 3000 mu g/plate and did not induce mutagenic effects after two oral administrations with a 24 h interval at a dose level of 2000 mg/kg. EEPA presented antileishmanial activity and presented an IC50 value of 5.35 +/- 2.50 mu g/mL and 4.50 +/- 1.17 mu g/mL against Leishmania amazonensis and Leishmania braziliensis promastigotes, respectively. In the cytotoxicity test against macrophages, the EEPA had a LC50 of 6.14 +/- 0.59 mu g/mL. Importantly, the IC50 against L. amazonensis intracellular amastigotes was 1.23 +/- 0.11 mu g/mL. Conclusion: EEPA extract is non-mutagenic and presented a promising pharmacological effect against Leishmania parasites. (c) 2013 Elsevier B.V. All rights reserved.

引用

页码：1304 / 1311

页数：8

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