Absence of 18F-fluorodeoxyglucose uptake using Positron Emission Tomography/Computed Tomography in Madelung's disease: A case report

被引：7
作者：
Moonen, Michiel P. B. [1 ]
Nascimento, Emmani B. M. [1 ]
van Kroonenburgh, Marinus J. P. G. [2 ]
Brandjes, Dees [3 ]
Lichtenbelt, Wouter D. van Marken [1 ]
机构：
[1] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Nutr & Movement Sci, Maastricht, Netherlands
[2] Maastricht Univ, Dept Nucl Med, Med Ctr, Maastricht, Netherlands
[3] Slotervaart Med Ctr, Dept Internal Med, Amsterdam, Netherlands
来源：
CLINICAL OBESITY | 2019年 / 9卷 / 03期
关键词：
brown adipose tissue; Madelung's disease; MULTIPLE SYMMETRIC LIPOMATOSIS; BROWN ADIPOSE-TISSUE;
D O I：
10.1111/cob.12302
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Madelung's disease is characterized by the manifestation of multiple ectopic lipomas, usually found in the cervical-thoracic region, however, clinical manifestation may vary among patients. It has been postulated that lipomas associated with Madelung's disease are linked to brown adipose tissue (BAT) due to the presence of uncoupling protein 1 (UCP1). Therefore, we here investigated whether BAT activity is present in a patient with Madelung's disease. F-18-fluorodeoxyglucose (F-18-FDG) uptake using PET/CT after a cooling procedure was measured together with body temperature and energy expenditure. Finally, adipose tissue biopsies were taken from the lipomas for gene expression analysis and histology. F-18-FDG uptake was not detected after the cooling procedure in the lipomas. Furthermore, adipose tissue biopsies derived from the lipomas did not express UCP1. We thus conclude that cold-stimulated BAT activity was not detected in lipomas associated with Madelung's disease. Additional research in other patients is needed to unravel the role of dysfunctional BAT in Madelung's disease.
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