Sustained enhancement of OCTN1 transporter expression in association with hydroxyurea induced γ-globin expression in erythroid progenitors

被引：6
作者：
Walker, Aisha L. [1 ,2 ]
Ofori-Acquah, Solomon F. [1 ,2 ,3 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Med,Vasc Med Inst, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Dept Med, Ctr Translat & Int Hematol,Vasc Med Inst, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Sch Med, Dept Med, Div Hematol Oncol,Vasc Med Inst, Pittsburgh, PA 15213 USA
来源：
EXPERIMENTAL HEMATOLOGY | 2017年 / 45卷
基金：
美国国家卫生研究院;
关键词：
UREA TRANSPORTER; CELLS; FETAL; DIFFERENTIATION; ERYTHROPOIESIS; PROLIFERATION; MECHANISM; PROTEIN; GENE;
D O I：
10.1016/j.exphem.2016.09.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The clinical benefits of hydroxyurea (HU) treatment in patients with sickle cell disease (SCD) are due largely to increased gamma-globin expression. However, mechanisms that control gamma-globin expression by HU in erythroid progenitors are incompletely understood. Here, we investigated the role of two HU transporters, urea transporter B (UTB) and organic cation/carnitine transporter 1 (OCTN1), in this process. Endogenous expression of both transporters peaked toward the end of erythroid differentiation. However, unlike UTB, HU-induced OCTN1 expression correlated positively with gamma-globin level and was sustained throughout the period of induction. These results highlight a potential major role for OCTN1 in promoting the efficacy of HU. Copyright (C) 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.
引用
收藏
页码：69 / 73
页数：5
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