Sustained enhancement of OCTN1 transporter expression in association with hydroxyurea induced γ-globin expression in erythroid progenitors

被引：6
作者：
Walker, Aisha L. [1 ,2 ]
Ofori-Acquah, Solomon F. [1 ,2 ,3 ]
机构：
[1] Univ Pittsburgh, Sch Med, Dept Med, Div Pulm Allergy & Crit Care Med,Vasc Med Inst, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Dept Med, Ctr Translat & Int Hematol,Vasc Med Inst, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Sch Med, Dept Med, Div Hematol Oncol,Vasc Med Inst, Pittsburgh, PA 15213 USA
来源：
EXPERIMENTAL HEMATOLOGY | 2017年 / 45卷
基金：
美国国家卫生研究院;
关键词：
UREA TRANSPORTER; CELLS; FETAL; DIFFERENTIATION; ERYTHROPOIESIS; PROLIFERATION; MECHANISM; PROTEIN; GENE;
D O I：
10.1016/j.exphem.2016.09.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The clinical benefits of hydroxyurea (HU) treatment in patients with sickle cell disease (SCD) are due largely to increased gamma-globin expression. However, mechanisms that control gamma-globin expression by HU in erythroid progenitors are incompletely understood. Here, we investigated the role of two HU transporters, urea transporter B (UTB) and organic cation/carnitine transporter 1 (OCTN1), in this process. Endogenous expression of both transporters peaked toward the end of erythroid differentiation. However, unlike UTB, HU-induced OCTN1 expression correlated positively with gamma-globin level and was sustained throughout the period of induction. These results highlight a potential major role for OCTN1 in promoting the efficacy of HU. Copyright (C) 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.
引用
收藏
页码：69 / 73
页数：5
相关论文
共 43 条
  • [1] Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation
    Nakamichi, Noritaka
    Taguchi, Takayuki
    Hosotani, Hiroshi
    Wakayama, Tomohiko
    Shimizu, Takuya
    Sugiura, Tomoko
    Iseki, Shoichi
    Kato, Yukio
    NEUROCHEMISTRY INTERNATIONAL, 2012, 61 (07) : 1121 - 1132
  • [2] NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression
    Starnes, Linda Marie
    Sorrentino, Antonio
    Pelosi, Elvira
    Ballarino, Monica
    Morsilli, Ornella
    Biffoni, Mauro
    Santoro, Simona
    Felli, Nadia
    Castelli, Germana
    De Marchis, Maria Laura
    Mastroberardino, Gianfranco
    Gabbianelli, Marco
    Fatica, Alessandro
    Bozzoni, Irene
    Nervi, Clara
    Peschle, Cesare
    BLOOD, 2009, 114 (09) : 1753 - 1763
  • [3] Novel histone deacetylase inhibitor CT-101 induces γ-globin gene expression in sickle erythroid progenitors with targeted epigenetic effects
    Junker, Louis H.
    Li, Biaoru
    Zhu, Xingguo
    Koti, Sivanagireddy
    Cerbone, Ryan E.
    Hendrick, Clifford L.
    Sangerman, Jose
    Perrine, Susan
    Pace, Betty S.
    BLOOD CELLS MOLECULES AND DISEASES, 2022, 93
  • [4] Enhancement of β-Globin Gene Expression in Thalassemic IVS2-654 Induced Pluripotent Stem Cell-Derived Erythroid Cells by Modified U7 snRNA
    Phanthong, Phetcharat
    Borwornpinyo, Suparerk
    Kitiyanant, Narisorn
    Jearawiriyapaisarn, Natee
    Nuntakarn, Lalana
    Saetan, Jirawat
    Nualkaew, Tiwaporn
    Sa-Ngiamsuntorn, Khanit
    Anurathapan, Usanarat
    Dinnyes, Andras
    Kitiyanant, Yindee
    Hongeng, Suradej
    STEM CELLS TRANSLATIONAL MEDICINE, 2017, 6 (04) : 1059 - 1069
  • [5] Hydroxyurea-inducible SAR1 gene acts through the Giα/JNK/Jun pathway to regulate γ-globin expression
    Zhu, Jianqiong
    Chin, Kyung
    Aerbajinai, Wulin
    Kumkhaek, Chutima
    Li, Hongzhen
    Rodgers, Griffin P.
    BLOOD, 2014, 124 (07) : 1146 - 1156
  • [6] KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
    Norton, Laura J.
    Funnell, Alister P. W.
    Burdach, Jon
    Wienert, Beeke
    Kurita, Ryo
    Nakamura, Yukio
    Philipsen, Sjaak
    Pearson, Richard C. M.
    Quinlan, Kate G. R.
    Crossley, Merlin
    BLOOD ADVANCES, 2017, 1 (11) : 685 - 692
  • [7] Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis)
    Ibanez, Vinzon
    Vaitkus, Kestis
    Ruiz, Maria Armila
    Lei, Zhengdeng
    Maienschein-Cline, Mark
    Arbieva, Zarema
    Lavelle, Donald
    PLOS ONE, 2023, 18 (12):
  • [8] Growth Factor Independence 1b (Gfi1b) Is Important for the Maturation of Erythroid Cells and the Regulation of Embryonic Globin Expression
    Vassen, Lothar
    Beauchemin, Hugues
    Lemsaddek, Wafaa
    Krongold, Joseph
    Trudel, Marie
    Moeroey, Tarik
    PLOS ONE, 2014, 9 (05):
  • [9] Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1
    Grieco, Amanda J.
    Billett, Henny H.
    Green, Nancy S.
    Driscoll, M. Catherine
    Bouhassira, Eric E.
    PLOS ONE, 2015, 10 (06):
  • [10] Neuronal expression of copper transporter 1 in rat dorsal root ganglia: association with platinum neurotoxicity
    Liu, Johnson J.
    Jamieson, Stephen M. F.
    Subramaniam, Joshuan
    Ip, Virginia
    Jong, Nancy N.
    Mercer, Julian F. B.
    McKeage, Mark J.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2009, 64 (04) : 847 - 856
12345