Obesity is a risk factor for atrial fibrillation among fertile young women: a nationwide cohort study

被引:53
作者
Karasoy, Deniz [1 ]
Jensen, Thomas Bo [1 ]
Hansen, Morten Lock [1 ]
Schmiegelow, Michelle [1 ]
Lamberts, Morten [1 ]
Gislason, Gunnar Hilmar [1 ]
Hansen, Jim [1 ]
Torp-Pedersen, Christian [1 ]
Olesen, Jonas Bjerring [1 ]
机构
[1] Copenhagen Univ Hosp Gentofte, Dept Cardiol, DK-2900 Hellerup, Denmark
来源
EUROPACE | 2013年 / 15卷 / 06期
关键词
Atrial fibrillation; Risk factors; Obesity; Epidemiology; Primary prevention; HEART; POPULATION; SIZE; MANAGEMENT; OVERWEIGHT; ALCOHOL; FLUTTER; IMPACT; INDEX; MEN;
D O I
10.1093/europace/eus422
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obesity has been associated with increased risk of atrial fibrillation (AF), but whether this risk is also prevalent in younger individuals is unknown. We therefore investigated the risk of AF in relation to body mass index (BMI) among young fertile women. By cross-linkage of nationwide registers of childbirth and hospitalization, we identified 271 203 women without prior AF who gave birth in Denmark between 2004 and 2009. Body mass index (kg/m(2)) was examined as a risk factor for AF using proportional hazard models. Mean age was 30.6 years (4.7 SD) and median follow-up was 4.6 years (interquartile range 2.95.8). During the follow-up, 110 women were hospitalized with first-time AF; very few individuals had known risk factors for AF. Overall incidence rate of AF was 9.3 [95 confidence interval (CI): 7.711.2] per 100 000 person-years. According to BMI, the incidence rate of AF per 100 000 person-years was 7.4 (5.69.7) in normal weight (BMI: 18.524.9), 8.5 (5.513.1) in overweight (BMI: 2529.9), 15.8 (9.326.7) in obese (BMI: 3035), and 27.3 (15.548.1) in very obese (BMI 35) individuals. Multivariable regression analyses adjusted for age, hyperthyroidism, and previous use of beta-blockers revealed a hazard ratio of 2.04 (95 CI: 1.133.69) in the obese and 3.50 (1.866.58) in the very obese individuals compared with normal weight. Obesity is a risk factor for AF among young and essentially healthy fertile women despite the low incidence of AF. These results may have implications for prevention of AF.
引用
收藏
页码:781 / 786
页数:6
相关论文
共 50 条
[21]   Obesity as a risk factor for the progression of paroxysmal to permanent atrial fibrillation: a longitudinal cohort study of 21 years [J].
Tsang, Teresa S. M. ;
Barnes, Marion E. ;
Miyasaka, Yoko ;
Cha, Stephen S. ;
Bailey, Kent R. ;
Verzosa, Grace C. ;
Seward, James B. ;
Gersh, Bernard J. .
EUROPEAN HEART JOURNAL, 2008, 29 (18) :2227-2233
[22]   Age at menopause and risk of heart failure and atrial fibrillation: a nationwide cohort study [J].
Shin, Jean ;
Han, Kyungdo ;
Jung, Jin Hyung ;
Park, Hyo Jin ;
Kim, Wonsock ;
Huh, Youn ;
Kim, Yang Hyun ;
Kim, Do Hoon ;
Kim, Seon Mee ;
Choi, Youn Seon ;
Cho, Kyung Hwan ;
Nam, Ga Eun .
EUROPEAN HEART JOURNAL, 2022, 43 (40) :4148-4157
[23]   Ankylosing spondylitis: A novel risk factor for atrial fibrillation - A nationwide population-based study [J].
Moon, Inki ;
Choi, Eue-Keun ;
Jung, Jin-Hyung ;
Han, Kyung-Do ;
Choi, You-Jung ;
Park, Jiesuck ;
Cho, Jun Hwan ;
Lee, Euijae ;
Choe, Wonseok ;
Lee, So-Ryoung ;
Cha, Myung-Jin ;
Lim, Woo-Hyun ;
Oh, Seil .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2019, 275 :77-82
[24]   Obesity, Physical Activity, and Their Interaction in Incident Atrial Fibrillation in Postmenopausal Women [J].
Azarbal, Farnaz ;
Stefanick, Marcia L. ;
Salmoirago-Blotcher, Elena ;
Manson, Joann E. ;
Albert, Christine M. ;
LaMonte, Michael J. ;
Larson, Joseph C. ;
Li, Wenjun ;
Martin, Lisa W. ;
Nassir, Rami ;
Garcia, Lorena ;
Assimes, Themistocles L. ;
Tharp, Katie M. ;
Hlatky, Mark A. ;
Perez, Marco V. .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2014, 3 (04)
[25]   Cirrhosis is a risk factor for atrial fibrillation: A nationwide, population-based study [J].
Lee, HyunJung ;
Choi, Eue-Keun ;
Rhee, Tae-Min ;
Lee, So-Ryoung ;
Lim, Woo-Hyun ;
Kang, Si-Hyuck ;
Han, Kyung-Do ;
Cha, Myung-Jin ;
Oh, Seil .
LIVER INTERNATIONAL, 2017, 37 (11) :1660-1667
[26]   Net Clinical Benefit of Oral Anticoagulation Among Frail Patients With Atrial Fibrillation: Nationwide Cohort Study [J].
Sogaard, Mette ;
Jensen, Martin ;
Hojen, Anette Arbjerg ;
Larsen, Torben Bjerregaard ;
Lip, Gregory Y. H. ;
Ording, Anne Gulbech ;
Nielsen, Peter Bronnum .
STROKE, 2024, 55 (02) :413-422
[27]   Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study [J].
Christiansen, Christine Benn ;
Torp-Pedersen, Christian ;
Olesen, Jonas Bjerring ;
Gislason, Gunnar ;
Lamberts, Morten ;
Carlson, Nicholas ;
Buron, Mathias ;
Juul, Nikolai ;
Lip, Gregory Y. H. .
BMC CARDIOVASCULAR DISORDERS, 2018, 18
[28]   Risk factor changes and incident atrial fibrillation among middle-aged men in the Malmo Preventive Project cohort [J].
Johnson, Linda S. B. ;
Juhlin, Tord ;
Engstrom, Gunnar ;
Nilsson, Peter M. .
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 2016, 2 (02) :81-87
[29]   Non-alcoholic Fatty Liver Disease and the Risk of Incident Atrial Fibrillation in Young Adults: A Nationwide Population-Based Cohort Study [J].
Choi, JungMin ;
Lee, So-Ryoung ;
Choi, Eue-Keun ;
Ahn, Hyo-Jeong ;
Kwon, Soonil ;
Park, Sang-Hyeon ;
Lee, HuiJin ;
Chung, Jaewook ;
Han, MinJu ;
Lee, Seung-Woo ;
Han, Kyung-Do ;
Oh, Seil ;
Lip, Gregory Y. H. .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2022, 9
[30]   High variability in bodyweight is associated with an increased risk of atrial fibrillation in patients with type 2 diabetes mellitus: a nationwide cohort study [J].
Lee, Hyun-Jung ;
Choi, Eue-Keun ;
Han, Kyung-Do ;
Kim, Da Hye ;
Lee, Euijae ;
Lee, So-Ryoung ;
Oh, Seil ;
Lip, Gregory Y. H. .
CARDIOVASCULAR DIABETOLOGY, 2020, 19 (01)