Exacerbation of tumor necrosis factor-induced vascular leak syndrome by aging

被引：1

作者：

Park, Kyung-Yeon ^{[1
]}

Kim, Sung-Jo ^{[2
]}

Oh, Euichaul ^{[1
]}

Heo, Tae-Hwe ^{[1
]}

机构：

[1] Catholic Univ Korea, Integrated Res Inst Pharmaceut Sci, Coll Pharm, Bucheon, South Korea

[2] Hoseo Univ, Dept Biotechnol, Asan, Chungnam, South Korea

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2015年 / 74卷

基金：

新加坡国家研究基金会;

关键词：

Aging; TNF; Vascular leak syndrome; VLS; FACTOR-ALPHA; TNF-ALPHA; ENDOTHELIAL DYSFUNCTION; INFLAMMATION; IMMUNOTHERAPY; CELLS; ATHEROSCLEROSIS; LYMPHOCYTES; ACTIVATION; INDUCTION;

D O I：

10.1016/j.biopha.2015.07.041

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aging is associated with upregulation of tumor necrosis factor (TNF) and increased vascular inflammation. TNF is a major proinflammatory cytokine that contributes to both vascular inflammation and vascular leak syndrome (VLS). The purpose of this study was to investigate whether the aging affects TNF-induced VLS. Vascular leak, histology, and cytokine assays were performed in young and aged groups of wild-type and TNF overexpressing transgenic (Tg) mice. An aged group of TNF Tg mice showed substantially amplified VLS compared with young Tg mice. Age-related amplification of TNF-induced VLS appears to be related to local vascular fibrosis and the systemic upregulation of TNF and MCP-1 levels in older TNF Tg mice. Our finding suggests that chronic high-grade TNF exposure could mediate the severe vascular pathogenicity of VLS. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：133 / 137

页数：5

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