Effect of sublingual administration of interferon-α on the immune response to influenza vaccination in institutionalized elderly individuals

被引：15

作者：

Launay, Odile ^{[2
,3
,4
]}

Grabar, Sophie ^{[2
,5
]}

Bloch, Frederic ^{[6
]}

Desaint, Corinne ^{[3
,4
]}

Jegou, David ^{[5
]}

Lallemand, Christophe ^{[1
]}

Erickson, Robert ^{[7
]}

Lebon, Pierre ^{[8
]}

Tovey, Michael G. ^{[1
]}

机构：

[1] Inst Andre Lwoff, CNRS, Lab Oncol Virale, FRE 2937, F-94801 Villejuif, France

[2] Univ Paris 05, Fac Med, Paris, France

[3] Grp Hosp Cochin St Vincent de Paul, AP HP, CIC Vaccinol Cochin Pasteur CIC BT505, Paris, France

[4] INSERM, CIC Vaccinol Cochin Pasteur, Paris, France

[5] Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Biostat, Paris, France

[6] Grp Hosp Broca La Rochefoucauld, AP HP, Serv Gerontol 1, Paris, France

[7] Orakine Ltd, Galway Technol Ctr, Galway, Ireland

[8] Grp Hosp Cochin St Vincent de Paul, AP HP, Serv Virol, Paris, France

来源：

VACCINE | 2008年 / 26卷 / 32期

关键词：

influenza vaccine; interferon; the elderly;

D O I：

10.1016/j.vaccine.2008.05.035

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A randomized double-blind placebo-controlled study was conducted to determine the effect of sublingual administration of IFN alpha on the immune response to influenza vaccination in elderly institutionalized individuals. Sublingual administration of 10 million IU of IFN alpha immediately prior to vaccination, reduced the geometric mean haemagglutination inhibitory (HAI) and IgG2 circulating antibody titers, and the secretory IgA (sIgA) response in saliva, to the New York strain of influenza A virus, 21 days post-vaccination, without detectable drug-related local or systemic toxicity. IFN treatment did not inhibit the immune response to the other components of the vaccine; the New Caledonia strain of influenza A virus, or the Jiangsu strain of influenza B virus. At the dose tested sublingual administration of IFN alpha reduces the immune response to influenza vaccination in elderly institutionalized individuals. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4073 / 4079

页数：7

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