Carbon nanotube delivery of the GFP gene into mammalian cells

被引：146
作者：
Gao, LZ
Nie, L
Wang, TH
Qin, YJ
Guo, ZX
Yang, DL
Yan, XY
机构：
[1] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Inst Chem, Beijing 10080, Peoples R China
[4] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
来源：
CHEMBIOCHEM | 2006年 / 7卷 / 02期
关键词：
gene expression; gene technology; green fluorescent protein; nanotechnology; nanotubes;
D O I：
10.1002/cbic.200500227
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Special delivery. Amino-functionalized multiwalled carbon nanotubes (NH2-MWCNTs) were found to interact with negatively charged DNA and the cell membrane (see figure). Through this interaction, NH2-MWCNTs successfully delivered the GFP (green fluorescent protein) gene into mammalian cells without any cytotoxicity. The results show that NH2-MWCNT is a novel gene carrier and has potential application in gene delivery. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：239 / 242
页数：4
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