Carbon nanotube delivery of the GFP gene into mammalian cells

被引：145

作者：

Gao, LZ

Nie, L

Wang, TH

Qin, YJ

Guo, ZX

Yang, DL

Yan, XY

机构：

[1] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Inst Chem, Beijing 10080, Peoples R China

[4] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 02期

关键词：

gene expression; gene technology; green fluorescent protein; nanotechnology; nanotubes;

D O I：

10.1002/cbic.200500227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Special delivery. Amino-functionalized multiwalled carbon nanotubes (NH2-MWCNTs) were found to interact with negatively charged DNA and the cell membrane (see figure). Through this interaction, NH2-MWCNTs successfully delivered the GFP (green fluorescent protein) gene into mammalian cells without any cytotoxicity. The results show that NH2-MWCNT is a novel gene carrier and has potential application in gene delivery. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：239 / 242

页数：4

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