Glycodelin is a potential novel follow-up biomarker for malignant pleural mesothelioma

被引：11

作者：

Schneider, Marc A. ^{[1
,6
]}

Muley, Thomas ^{[1
,6
]}

Kahn, Nicolas C. ^{[1
,4
,6
]}

Warth, Arne ^{[2
,6
]}

Thomas, Michael ^{[3
,6
]}

Herth, Felix J. F. ^{[4
,6
]}

Dienemann, Hendrik ^{[5
,6
]}

Meister, Michael ^{[1
,6
]}

机构：

[1] Univ Heidelberg Hosp, Thoraxklin, Translat Res Unit, Roentgenstr, Heidelberg, Germany

[2] Heidelberg Univ, Inst Pathol, Heidelberg, Germany

[3] Univ Heidelberg Hosp, Thoraxklin, Dept Thorac Oncol, Roentgenstr, Heidelberg, Germany

[4] Univ Heidelberg Hosp, Thoraxklin, Dept Pneumol & Crit Care Med, Roentgenstr, Heidelberg, Germany

[5] Univ Heidelberg Hosp, Thoraxklin, Dept Surg, Roentgenstr, Heidelberg, Germany

[6] German Ctr Lung Res, Translat Lung Res Ctr Heidelberg, Heidelberg, Germany

来源：

ONCOTARGET | 2016年 / 7卷 / 44期

关键词：

MPM; glycodelin; SMRP; biomarker; follow-up; LUNG-CANCER; OSTEOPONTIN; FIBULIN-3; DIAGNOSIS; PROTEINS; BENIGN; EXPRESSION; APOPTOSIS; EFFECTOR; DISEASE;

D O I：

10.18632/oncotarget.12474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with a short survival time arising from the mesothelial cells of the pleura. Soluble mesothelin-related peptide (SMRP), osteopontin or EFEMP1 (Fibulin-3) are well described biomarkers for malignant mesothelioma with moderate sensitivity and specificity. In this study, we characterized the expression of glycodelin, a marker for risk pregnancy, in MPM by RNA and protein analyses and investigated its potential as a MPM biomarker. We were able to detect glycodelin in the serum of MPM patients. Compared to benign lung diseases, the serum levels were significant increased. Patients with high glycodelin serum levels revealed a worse overall survival. The glycodelin serum levels correlated with the tumor response to treatment. A comparison of SMRP and glycodelin serum measurement in a large patient cohort demonstrated that the detection of both soluble factors can increase the reliable diagnostic of MPM. Glycodelin was highly expressed in MPM tumors. Analyses of a tissue micro array indicated that the immunomodulatory form glycodelin A was expressed in MPM and correlated with the survival of the patients. Altogether, glycodelin seems to be a new potential biomarker for the aggressive malignant pleural mesothelioma.

引用

页码：71285 / 71297

页数：13

共 44 条

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