Leukocyte Behavior in Atherosclerosis, Myocardial Infarction, and Heart Failure

被引：857

作者：

Swirski, Filip K. ^{[1
]}

Nahrendorf, Matthias

机构：

[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

来源：

SCIENCE | 2013年 / 339卷 / 6116期

关键词：

STEM-CELL PROLIFERATION; DENDRITIC CELLS; HEMATOPOIETIC STEM; MONOCYTE SUBSETS; INFLAMMATORY RESPONSES; PROGENITOR CELLS; APOLIPOPROTEIN-E; PROTECTIVE ROLE; DEFICIENT MICE; T-LYMPHOCYTES;

D O I：

10.1126/science.1230719

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cardiovascular diseases claim more lives worldwide than any other. Etiologically, the dominant trajectory involves atherosclerosis, a chronic inflammatory process of lipid-rich lesion growth in the vascular wall that can cause life-threatening myocardial infarction (MI). Those who survive MI can develop congestive heart failure, a chronic condition of inadequate pump activity that is frequently fatal. Leukocytes (white blood cells) are important participants at the various stages of cardiovascular disease progression and complication. This Review will discuss leukocyte function in atherosclerosis, MI, and heart failure.

引用

页码：161 / 166

页数：6

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