Optimization of cooling strategy and seeding by FBRM analysis of batch crystallization

被引：29
作者：
Zhang, Dejiang [1 ,2 ]
Liu, Lande [3 ]
Xu, Shijie [1 ,2 ]
Du, Shichao [1 ,2 ]
Dong, Weibing [1 ,2 ]
Gong, Junbo [1 ,2 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China
[3] Univ Huddersfield, Sch Appl Sci, Huddersfield HD1 3DH, W Yorkshire, England
来源：
JOURNAL OF CRYSTAL GROWTH | 2018年 / 486卷
基金：
中国国家自然科学基金;
关键词：
Batch crystallization; Constant growth rate trajectory; FBRM; Optimized seed policy; Optimization; CRYSTAL SIZE DISTRIBUTION; DIRECT NUCLEATION CONTROL; DESIGN; DISTRIBUTIONS; PERSPECTIVE; ZONE;
D O I：
10.1016/j.jcrysgro.2017.12.046
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
A method is presented for optimizing the cooling strategy and seed loading simultaneously. Focused beam reflectance measurement (FBRM) was used to determine the approximating optimal cooling profile. Using these results in conjunction with constant growth rate assumption, modified Mullin-Nyvlt trajectory could be calculated. This trajectory could suppress secondary nucleation and has the potential to control product's polymorph distribution. Comparing with linear and two step cooling, modified Mullin-Nyvlt trajectory have a larger size distribution and a better morphology. Based on the calculating results, the optimized seed loading policy was also developed. This policy could be useful for guiding the batch crystallization process. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：1 / 9
页数：9
相关论文
共 50 条
[41]   Cooling and seeding effect on supersaturation and final crystal size distribution (CSD) of ammonium sulphate in a batch crystallizer [J].
Hojjati, H ;
Rohani, S .
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2005, 44 (09) :949-957
[42]   Dynamic Modeling and Optimization of Batch Crystallization of Sugar Cane under Uncertainty [J].
Bolanos-Reynoso, Eusebio ;
Sanchez-Sanchez, Kelvyn B. ;
Urrea-Garcia, Galo R. ;
Ricardez-Sandoval, Luis .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2014, 53 (33) :13180-13194
[43]   Robust optimal temperature swing operations for size control of seeded batch cooling crystallization [J].
Seki, Hiroya ;
Su, Ye .
CHEMICAL ENGINEERING SCIENCE, 2015, 133 :16-23
[44]   Automated direct nucleation control for in situ dynamic fines removal in batch cooling crystallization [J].
Saleemi, Ali ;
Rielly, Chris ;
Nagy, Zoltan K. .
CRYSTENGCOMM, 2012, 14 (06) :2196-2203
[45]   Modeling of Nucleation and Growth Kinetics for Unseeded Batch Cooling Crystallization [J].
Li, Huayu ;
Kawajiri, Yoshiaki ;
Grover, Martha A. ;
Rousseau, Ronald W. .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2017, 56 (14) :4060-4073
[46]   Crystal growth rate dispersion in sugar batch cooling crystallization [J].
Grbic, Jasna ;
Jevtic-Mucibabic, Rada ;
Kuljanin, Tatjana ;
Filipcev, Bojana ;
Simurina, Olivera .
INTERNATIONAL SUGAR JOURNAL, 2014, 116 (1392) :902-905
[47]   Modeling of Nucleation, Growth, and Dissolution of Paracetamol in Ethanol Solution for Unseeded Batch Cooling Crystallization with Temperature-Cycling Strategy [J].
Kim, Youngjo ;
Kawajiri, Yoshiaki ;
Rousseau, Ronald W. ;
Grover, Martha A. .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2023, 62 (06) :2866-2881
[48]   Effect of initial dextrose concentration, seeding and cooling profile on the crystallization of dextrose monohydrate [J].
Markande, Abhay ;
Fitzpatrick, John ;
Nezzal, Amale ;
Aerts, Luc ;
Redl, Andreas .
FOOD AND BIOPRODUCTS PROCESSING, 2012, 90 (C3) :406-412
[49]   Optimization of semi-batch reactive crystallization processes [J].
Choong, KL ;
Smith, R .
CHEMICAL ENGINEERING SCIENCE, 2004, 59 (07) :1529-1540
[50]   A generic multi-dimensional model-based system for batch cooling crystallization processes [J].
Samad, Noor Asma Fazli Abdul ;
Singh, Ravendra ;
Sin, Gurkan ;
Gernaey, Krist V. ;
Gani, Rafiqul .
COMPUTERS & CHEMICAL ENGINEERING, 2011, 35 (05) :828-843
12345