Neuroactive Insecticides: Targets, Selectivity, Resistance, and Secondary Effects

被引：599
作者：
Casida, John E. [1 ]
Durkin, Kathleen A. [2 ]
机构：
[1] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Environm Chem & Toxicol Lab, Berkeley, CA 94720 USA
[2] Univ Calif Berkeley, Coll Chem, Mol Graph & Computat Facil, Berkeley, CA 94720 USA
来源：
ANNUAL REVIEW OF ENTOMOLOGY, VOL 58 | 2013年 / 58卷
基金：
美国国家科学基金会;
关键词：
acetylcholinesterase; calcium channels; GABA(A) receptor; nicotinic receptor; secondary targets; sodium channel; GATED CHLORIDE CHANNEL; NICOTINIC ACETYLCHOLINE-RECEPTORS; NEONICOTINOID INSECTICIDES; BINDING-SITE; PARKINSONS-DISEASE; PESTICIDE EXPOSURE; HIGH-AFFINITY; ION CHANNELS; H-3; EBOB; BRAIN;
D O I：
10.1146/annurev-ento-120811-153645
中图分类号：
Q96 [昆虫学];
学科分类号：
摘要：
Neuroactive insecticides are the principal means of protecting crops, people, livestock, and pets from pest insect attack and disease transmission. Currently, the four major nerve targets are acetylcholinesterase for organophosphates and methylcarbamates, the nicotinic acetylcholine receptor for neonicotinoids, the gamma-aminobutyric acid receptor/chloride channel for polychlorocyclohexanes and fiproles, and the voltage-gated sodium channel for pyrethroids and dichlorodiphenyltrichloroethane. Species selectivity and acquired resistance are attributable in part to structural differences in binding subsites, receptor subunit interfaces, or transmembrane regions. Additional targets are sites in the sodium channel (indoxacarb and metaflumizone), the glutamate-gated chloride channel (avermectins), the octopamine receptor (amitraz metabolite), and the calcium-activated calcium channel (diamides). Secondary toxic effects in mammals from off-target serine hydrolase inhibition include organophosphate-induced delayed neuropathy and disruption of the cannabinoid system. Possible associations between pesticides and Parkinson's and Alzheimer's diseases are proposed but not established based on epidemiological observations and mechanistic considerations.
引用
收藏
页码：99 / 117
页数：19
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