Concomitant hairy cell and acute myeloid leukemia

被引：7

作者：

Rimner, T

Went, P

Tichelli, A

Gratwohl, A ^{[1
]}

机构：

[1] Univ Basel Hosp, Div Hematol, Dept Internal Med, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Dept Med, CH-4031 Basel, Switzerland

[3] Univ Basel Hosp, Dept Pathol, CH-4031 Basel, Switzerland

[4] Univ Basel Hosp, Hematol Lab, CH-4031 Basel, Switzerland

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2006年 / 76卷 / 01期

关键词：

concomitant leukemias; acute myeloid leukemia; hairy cell leukemia; secondary malignancy; purine analoga;

D O I：

10.1111/j.0902-4441.0000.t01-1-EJH2356.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Secondary malignancies in patients with hairy cell leukemia (HCL) are well described and treatment of HCL is discussed as their cause. We describe a 58-yr-old patient who presented with both acute myeloid leukemia (AML) and HCL at the same time. Treatment with cladribine, daunorubicin and cytosine arabinoside, followed by autologous stem cell transplantation, induced complete remission of AML and hematologic remission of HCL for 22 months, when he relapsed with AML. This concomitant occurrence of AML and HCL is suggestive of a genetic predisposition rather then coincidence or relation to purine analoga.

引用

页码：86 / 88

页数：3

共 9 条

[1] Second malignancies as a consequence of nucleoside analog therapy for chronic lymphoid leukemias [J].