Two new compounds from an Indonesian sponge Dysidea sp.

被引：11

作者：

Trianto, Agus ^{[1
,2
]}

de Voodg, Nicole J. ^{[3
]}

Tanaka, Junichi ^{[4
]}

机构：

[1] Diponegoro Univ, Dept Marine Sci, Tembalang Semarang 50275, Central Java, Indonesia

[2] Diponegoro Univ, Cent Lab Res & Serv, UPT Lab Terpadu, Tembalang Semarang 50239, Central Java, Indonesia

[3] Naturalis, Netherlands Ctr Biodivers, NL-2300 RA Leiden, Netherlands

[4] Univ Ryukyus, Dept Chem Biol & Marine Sci, Nishihara, Okinawa 9030213, Japan

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 02期

关键词：

FRAGILIS; AZACYCLOPROPENE; HYDROQUINONE; DERIVATIVES; INHIBITORS; HERBACEA; ACID;

D O I：

10.1080/10286020.2013.844128

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

On our joint bioprospecting research on Indonesian marine invertebrates, we found moderate cytotoxicity on an extract of the sponge Dysidea sp. collected at Biak, West Papua. Separation of the extract provided two new compounds, biaketide (1) and debromoantazirine (2), along with four known molecules 3-6. The new structures were elucidated by spectroscopic analyses and by comparison with those reported. Compounds 1 and 2 showed moderate cytotoxicity against NBT-T2 cells with IC50 values of 8.3 and 4.7 g ml- 1, respectively. © 2013 Taylor & Francis.

引用

页码：163 / 168

页数：6

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