PD-L1 copy number gains: a predictive biomarker for PD-1/PD-L1 blockade therapy?

被引：3

作者：

Inoue, Yusuke ^{[1
,2
]}

Osman, Murat ^{[1
,3
]}

Suda, Takafumi ^{[2
]}

Sugimura, Haruhiko ^{[1
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Internal Med, Dept Tumor Pathol, Hamamatsu, Shizuoka, Japan

[2] Hamamatsu Univ Sch Med, Dept Internal Med, Div 2, Hamamatsu, Shizuoka, Japan

[3] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA

来源：

TRANSLATIONAL CANCER RESEARCH | 2016年 / 5卷

关键词：

OPEN-LABEL; NIVOLUMAB; EXPRESSION; DOCETAXEL; MULTICENTER; MELANOMA;

D O I：

10.21037/tcr.2016.07.47

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：S199 / S202

页数：4

共 25 条

[1] Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors [J].

Akbay, Esra A. ;

Koyama, Shohei ;

Carretero, Julian ;

Altabef, Abigail ;

Tchaicha, Jeremy H. ;

Christensen, Camilla L. ;

Mikse, Oliver R. ;

Cherniack, Andrew D. ;

Beauchamp, Ellen M. ;

Pugh, Trevor J. ;

Wilkerson, Matthew D. ;

Fecci, Peter E. ;

Butaney, Mohit ;

Reibel, Jacob B. ;

Soucheray, Margaret ;

Cohoon, Travis J. ;

Janne, Pasi A. ;

Meyerson, Matthew ;

Hayes, D. Neil ;

Shapiro, Geoffrey I. ;

Shimamura, Takeshi ;

Sholl, Lynette M. ;

Rodig, Scott J. ;

Freeman, Gordon J. ;

Hammerman, Peter S. ;

Dranoff, Glenn ;

Wong, Kwok-Kin .

CANCER DISCOVERY, 2013, 3 (12) :1355-1363

[2] PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma [J].

Ansell, Stephen M. ;

Lesokhin, Alexander M. ;

Borrello, Ivan ;

Halwani, Ahmad ;

Scott, Emma C. ;

Gutierrez, Martin ;

Schuster, Stephen J. ;

Millenson, Michael M. ;

Cattry, Deepika ;

Freeman, Gordon J. ;

Rodig, Scott J. ;

Chapuy, Bjoern ;

Ligon, Azra H. ;

Zhu, Lili ;

Grosso, Joseph F. ;

Kim, Su Young ;

Timmerman, John M. ;

Shipp, Margaret A. ;

Armand, Philippe .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (04) :311-319

[3] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[4] Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer [J].

Brahmer, Julie ;

Reckamp, Karen L. ;

Baas, Paul ;

Crino, Lucio ;

Eberhardt, Wilfried E. E. ;

Poddubskaya, Elena ;

Antonia, Scott ;

Pluzanski, Adam ;

Vokes, Everett E. ;

Holgado, Esther ;

Waterhouse, David ;

Ready, Neal ;

Gainor, Justin ;

Aren Frontera, Osvaldo ;

Havel, Libor ;

Steins, Martin ;

Garassino, Marina C. ;

Aerts, Joachim G. ;

Domine, Manuel ;

Paz-Ares, Luis ;

Reck, Martin ;

Baudelet, Christine ;

Harbison, Christopher T. ;

Lestini, Brian ;

Spigel, David R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (02) :123-135

[5] Pan-Cancer Analysis of Copy Number Changes in Programmed Death-Ligand 1 (PD-L1, CD274) - Associations with Gene Expression, Mutational Load, and Survival [J].

Budczies, Jan ;

Bockmayr, Michael ;

Denkert, Carsten ;

Klauschen, Frederick ;

Groeschel, Stefan ;

Darb-Esfahani, Silvia ;

Pfarr, Nicole ;

Leichsenring, Jonas ;

Onozato, Maristela L. ;

Lennerz, Jochen K. ;

Dietel, Manfred ;

Froehling, Stefan ;

Schirmacher, Peter ;

Iafrate, A. John ;

Weichert, Wilko ;

Stenzinger, Albrecht .

GENES CHROMOSOMES & CANCER, 2016, 55 (08) :626-639

[6] Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas [J].

Campbell, Joshua D. ;

Alexandrov, Anton ;

Kim, Jaegil ;

Wala, Jeremiah ;

Berger, Alice H. ;

Pedamallu, Chandra Sekhar ;

Shukla, Sachet A. ;

Guo, Guangwu ;

Brooks, Angela N. ;

Murray, Bradley A. ;

Imielinski, Marcin ;

Hu, Xin ;

Ling, Shiyun ;

Akbani, Rehan ;

Rosenberg, Mara ;

Cibulskis, Carrie ;

Ramachandran, Aruna ;

Collisson, Eric A. ;

Kwiatkowski, David J. ;

Lawrence, Michael S. ;

Weinstein, John N. ;

Verhaak, Roel G. W. ;

Wu, Catherine J. ;

Hammerman, Peter S. ;

Cherniack, Andrew D. ;

Getz, Gad ;

Artyomov, Maxim N. ;

Schreiber, Robert ;

Govindan, Ramaswamy ;

Meyerson, Matthew .

NATURE GENETICS, 2016, 48 (06) :607-+

[7] New immunotherapies targeting the PD-1 pathway [J].

Chinai, Jordan M. ;

Janakiram, Murali ;

Chen, Fuxiang ;

Chen, Wantao ;

Kaplan, Mark ;

Zang, Xingxing .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2015, 36 (09) :587-595

[8] Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy [J].

Coulie, Pierre G. ;

Van den Eynde, Benoit J. ;

van der Bruggen, Pierre ;

Boon, Thierry .

NATURE REVIEWS CANCER, 2014, 14 (02) :135-146

[9] Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial [J].

Fehrenbacher, Louis ;

Spira, Alexander ;

Ballinger, Marcus ;

Kowanetz, Marcin ;

Vansteenkiste, Johan ;

Mazieres, Julien ;

Park, Keunchil ;

Smith, David ;

Artal-Cortes, Angel ;

Lewanski, Conrad ;

Braiteh, Fadi ;

Waterkamp, Daniel ;

He, Pei ;

Zou, Wei ;

Chen, Daniel S. ;

Yi, Jing ;

Sandler, Alan ;

Rittmeyer, Achim .

LANCET, 2016, 387 (10030) :1837-1846

[10]

Gainor JF, 2016, CLIN CANC RES

← 1 2 3 →