Synthesis and Anticancer Activity of Novel Coumarin Derivatives

被引：4

作者：

Shi, Lei ^{[1
]}

Li, Ziqiu ^{[1
]}

Cui, Xinxin ^{[2
]}

Zhu, Ting ^{[2
]}

Pang, Xiaojing ^{[2
]}

Li, Longhui ^{[1
]}

Luo, Defu ^{[1
]}

Liu, Fangfang ^{[2
]}

Zhao, Bingyu ^{[2
]}

Long, Yue ^{[1
]}

Zhang, Saiyang ^{[3
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

[2] Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[3] Zhengzhou Univ, Sch Basic Med Sci, Zhengzhou 450001, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 40卷 / 06期

基金：

中国博士后科学基金;

关键词：

coumarin; anticancer; synthesis; AMIDE;

D O I：

10.6023/cjoc201911028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nineteen novel 3,4,5-trimethoxyphenvl coumarin derivatives have been synthesized and evaluated for antitumor activity against three human cancer cell lines (EC-109, PC-3 and MGC-803). These chemical structures were well characterized by NMR and HRMS spectroscopic methods. N-Benzyl-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-N-(3,4,5-trimethoxyphenyl)acetamide) (4a) and N-((5-chlorobenzo[b]thiophen-3-yl)methyl)-2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy-N-(3,4,5-trimethoxyphenyl)acetamide) (4n) had better inhibitory activity against three kinds of tumor cells than 5-fluorouracil. Compound 4n showed the most potent antitumor activity against PC-3 cells with an IC50 value of 4.18 mu mol/L.

引用

页码：1598 / 1607

页数：10

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