Application of the Fe3O4@1,10-phenanthroline-5,6-diol@Mn nano-catalyst for the green synthesis of tetrazoles and its biological performance

被引：15

作者：

Habibi, Davood ^{[1
]}

Heydari, Somayyeh ^{[1
]}

Gil, Antonio ^{[2
]}

Afsharfarnia, Mina ^{[1
]}

Faraji, Alireza ^{[3
]}

Karamian, Roya ^{[4
]}

Asadbegy, Mostafa ^{[4
]}

机构：

[1] Bu Ali Sina Univ, Dept Organ Chem, Fac Chem, Hamadan 6517838683, Iran

[2] Univ Publ Navarra, Dept Appl Chem, Bldg Los Acebos,Campus Arrosadia, E-31006 Pamplona, Spain

[3] Islamic Azad Univ, Pharmaceut Sci Branch, Young Researchers & Elite Club, Tehran, Iran

[4] Bu Ali Sina Univ, Dept Biol, Fac Sci, Hamadan 6517838683, Iran

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2018年 / 32卷 / 02期

关键词：

1; 10-phenanthroline-5; 6-diol; biological performance; catalyst; Fe3O4 magnetic particle; tetrazoles; REUSABLE HETEROGENEOUS CATALYST; 5-SUBSTITUTED; 1H-TETRAZOLES; FACILE SYNTHESIS; ANTIOXIDANT; CYCLOADDITION; NANOPARTICLES; DERIVATIVES; CHEMISTRY; EFFICIENT; COMPLEX;

D O I：

10.1002/aoc.4005

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The Fe3O4 magnetic particles were modified with 1,10-phenanthroline-5,6-diol (Phen) and the related Mn complex (Fe3O4@Phen@Mn) synthesized as a heterogeneous catalyst to be used for the one-pot three-component synthesis of various tetrazoles. The catalysts were characterized by several methods, such as the elemental analysis, FT-IR, X-ray powder diffraction, dispersive X-ray spectroscopy, scanning electron microscopy, transmission electron microscopy, dynamic light scattering, thermogravimetric-differential thermal analysis, vibrating sample magnetometer and X-ray photoelectron spectroscopy. In addition, the antioxidant and antibacterial activities of the catalyst and its Phen ligand were in vitro screened with 2,2-diphenyl-1-picrylhydrazyl by free radical scavenging methods. Results showed that the synthesized compounds possess strong antioxidant activity (IC50; 0.172 +/- 0.005mgml(-1)) as well as a good antibacterial potential in comparison to standards.

引用

页数：8

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