Fragile X syndrome: An aging perspective

被引：17
作者：
Schneider, Andrea [1 ,2 ]
Ligsay, Andrew [1 ,2 ]
Hagerman, Randi J. [1 ,2 ]
机构：
[1] Univ Calif Davis, MIND Inst, Med Ctr, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Dept Pediat, Med Ctr, Sacramento, CA 95817 USA
来源：
DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS | 2013年 / 18卷 / 01期
关键词：
fragile X syndrome; aging; neurodegeneration; FMRP; AUTISM SPECTRUM DISORDER; FMR1; MESSENGER-RNA; MENTAL-RETARDATION PROTEIN; TREMOR/ATAXIA SYNDROME; PREMUTATION CARRIERS; LONGITUDINAL CHANGES; FULL MUTATION; ADAPTIVE-BEHAVIOR; INFANTILE-AUTISM; INTRANUCLEAR INCLUSIONS;
D O I：
10.1002/ddrr.1129
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Cognitive and behavioral correlates of molecular variations related to the FMR1 gene have been studied rather extensively, but research about the long-term outcome in individuals with fragile X spectrum disorders remains sparse. In this review, we present an overview of aging research and recent findings in regard to cellular and clinical manifestations of aging in fragile X syndrome, and the FMR1 premutation. (c) 2013 Wiley Periodicals, Inc. Dev Disabil Res Rev 2013;18:68-74.
引用
收藏
页码：68 / 74
页数：7
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