A patient with multiple myeloma, amyloidosis and light-chain deposition disease in kidneys with a long survival

被引：7

作者：

Christou, L

Hatzimichael, EC

Sotsiou-Candila, F

Siamopoulos, K

Bourantas, KL

机构：

[1] Univ Ioannina, Ioannina Med Sch, Dept Internal Med, Haematol Unit, GR-45110 Ioannina, Greece

[2] Univ Ioannina, Ioannina Med Sch, Dept Internal Med, Nephrol Clin, GR-45110 Ioannina, Greece

[3] Evangelismos Hosp, Dept Pathol, Athens, Greece

来源：

ACTA HAEMATOLOGICA | 1999年 / 101卷 / 04期

关键词：

amyloidosis; interferon-alpha; 2b; light-chain deposition disease; long survival; multiple myeloma;

D O I：

10.1159/000040954

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of a 39-year-old man with lambda-light-chain multiple myeloma, nephrotic syndrome due to lambda-light-chain deposition disease in kidneys and amyloidosis in other tissues. The patient was treated with melphalan and prednisone for 1 year. After that, he was administered interferon-alpha 2b (IFN-alpha 2b; 3 MU, 3 times a week) as maintenance therapy for 2 years. At present, 5 years and 6 months after the initial diagnosis, the patient receives IFN-alpha 2b (3 MU, twice a week) and remains in complete haematological remission.

引用

页码：202 / 205

页数：4

共 18 条

[1] AMYLOIDOSIS IN MULTIPLE-MYELOMA OR WITHOUT APPARENT CAUSE [J].

ALEXANIAN, R ;

FRASCHINI, G ;

SMITH, L .

ARCHIVES OF INTERNAL MEDICINE, 1984, 144 (11) :2158-2160

[2] SYSTEMIC AMYLOIDOSIS AND THE SKIN - REVIEW WITH SPECIAL EMPHASIS ON CLINICAL-FEATURES AND THERAPY [J].

BREATHNACH, SM ;

BLACK, MM .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1979, 4 (04) :517-536

[3] MECHANISMS OF DISEASE - MONOCLONAL IMMUNOGLOBULIN DEPOSITION - AMYLOIDOSIS, LIGHT CHAIN DEPOSITION DISEASE, AND LIGHT AND HEAVY-CHAIN DEPOSITION DISEASE [J].

BUXBAUM, J .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 1992, 6 (02) :323-346

[4] MONOCLONAL IMMUNOGLOBULIN DEPOSITION DISEASE - LIGHT CHAIN AND LIGHT AND HEAVY-CHAIN DEPOSITION DISEASES AND THEIR RELATION TO LIGHT CHAIN AMYLOIDOSIS - CLINICAL-FEATURES, IMMUNOPATHOLOGY, AND MOLECULAR ANALYSIS [J].

BUXBAUM, JN ;

CHUBA, JV ;

HELLMAN, GC ;

SOLOMON, A ;

GALLO, GR .

ANNALS OF INTERNAL MEDICINE, 1990, 112 (06) :455-464

[5]

COHEN JJ, 1985, KIDNEY INT, V27, P582

[6] LIGHT-CHAIN DEPOSITION DISEASE - ITS RELATION WITH AL-TYPE AMYLOIDOSIS [J].

GANEVAL, D ;

NOEL, LH ;

PREUDHOMME, JL ;

DROZ, D ;

GRUNFELD, JP .

KIDNEY INTERNATIONAL, 1984, 26 (01) :1-9

[7] AMYLOID FIBRIL PROTEINS - PROOF OF HOMOLOGY WITH IMMUNOGLOBULIN LIGHT CHAINS BY SEQUENCE ANALYSES [J].

GLENNER, GG ;

TERRY, W ;

HARADA, M ;

ISERSKY, C ;

PAGE, D .

SCIENCE, 1971, 172 (3988) :1150-&

[8] MULTIPLE-MYELOMA IN YOUNG PERSONS [J].

HEWELL, GM ;

ALEXANIAN, R .

ANNALS OF INTERNAL MEDICINE, 1976, 84 (04) :441-443

[9] Interferon-alpha 2b added to melphalan-prednisone for initial and maintenance therapy in multiple myeloma - A randomized, controlled trial [J].

Hjorth, M ;

Westin, J ;

Dahl, IMS ;

Gimsing, P ;

Hippe, E ;

Holmberg, E ;

Lamvik, J ;

Nielsen, JL ;

Lofvenberg, E ;

Palva, IP ;

Rodjer, S ;

Talstad, I ;

Turesson, I ;

Wisloff, F ;

Zador, G ;

AmslerNordin, S ;

Polgary, M ;

Oden, A ;

Wallgren, A ;

Wilhelmsen, L ;

Hellqvist, L ;

Hasselblom, S ;

Carneskog, J ;

Lindqvist, O ;

Hoffman, P ;

Olsson, K ;

Tholen, A ;

Stolt, CM ;

Rindner, A ;

Svensson, R ;

Vaart, J ;

Hansen, S ;

Engqvist, L ;

Lannemyr, O ;

Nilsson, PG ;

Linne, I ;

Lilja, G ;

Tallroth, G ;

Hallgren, J ;

Andersson, B ;

Billstrom, R ;

Persson, S ;

Samuelsson, T ;

Odeberg, H ;

Adriansson, M ;

Tove, H ;

Stobeus, N ;

Habberstad, J ;

End, T ;

Dahlen, M .

ANNALS OF INTERNAL MEDICINE, 1996, 124 (02) :212-+

[10]

JACQUOT C, 1985, CLIN NEPHROL, V24, P93

← 1 2 →