Synthesis, Characterization and Biological Activities of a Schiff Base Derived from 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide and its Complexes with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) Ions

被引：0

作者：

Gulzar, Aqsa ^{[1
]}

Mahmud, Tariq ^{[1
]}

Mitu, Liviu ^{[2
]}

Munir, Rubina ^{[3
]}

Imran, Muhammad ^{[1
]}

Iftikhar, Kiran ^{[4
]}

机构：

[1] Univ Punjab, Inst Chem, Lahore 54590, Pakistan

[2] Univ Pitesti, Dept Chem, 1 Targu Vale Str, Pitesti 110040, Romania

[3] Kinnaird Coll Women, Dept Chem, Lahore, Pakistan

[4] Univ Gujrat, Dept Chem, Gujrat, Pakistan

来源：

REVISTA DE CHIMIE | 2019年 / 70卷 / 02期

关键词：

Schiff base; metal complexes; anti-inflammatory activity; TRANSITION-METAL-COMPLEXES; MANNICH BASE; DERIVATIVES; INHIBITORS; OLEFINS; FE(II);

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new Schiff base ligand from 2-[(1,3-benzothiazol-2-yl)sulfanyl]-N-[4-(hydrazinecarbonyl)phenyl]acetamide (BHA) and its five metal complexes with transition metal ions [Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)] have been synthesized. The resulting compounds were subsequently characterized by FTIR, UV-Vis, AAS, H-1 NMR, C-13 NMR and mass spectrometry. The proposed geometries of the Schiff base metal complexes were established on the basis of metal/ligand ratio, through AAS/ICP, electronic spectroscopy and magnetic data. The synthesized Schiff base and its complexes were further investigated for their anti-inflammatory and anticancer activity which exhibited relatively pronounced activity for metal complexes than Schiff base.

引用

页码：596 / 601

页数：6

共 42 条

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