Inflammatory and thrombotic changes in early bereavement: a prospective evaluation

被引：38

作者：

Buckley, Thomas ^{[1
,2
]}

Morel-Kopp, Marie-Christine ^{[3
,4
]}

Ward, Christopher ^{[3
,4
]}

Bartrop, Roger ^{[4
,5
]}

McKinley, Sharon ^{[6
]}

Mihailidou, Anastasia Susie ^{[1
,4
]}

Spinaze, Monica ^{[1
]}

Chen, Walter ^{[3
,4
]}

Tofler, Geoffrey ^{[1
,4
]}

机构：

[1] Royal N Shore Hosp, Dept Cardiol, Sydney, NSW, Australia

[2] Univ Sydney, Sydney Nursing Sch, Sydney, NSW 2006, Australia

[3] Royal N Shore Hosp, Dept Haematol & Transfus Med, Sydney, NSW, Australia

[4] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[5] Royal N Shore Hosp, Dept Psychol Med, Sydney, NSW, Australia

[6] Univ Technol Sydney, Fac Nursing Midwifery & Hlth, Sydney, NSW 2007, Australia

来源：

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY | 2012年 / 19卷 / 05期

关键词：

Bereavement; inflammation; thrombotic changes; von Willebrand; platelet; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; CONJUGAL BEREAVEMENT; ELEVATED LEVELS; IMMUNE FUNCTION; STRESS; RISK; DEPRESSION; MARKERS; MORTALITY;

D O I：

10.1177/1741826711421686

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: Although there is an increased cardiovascular risk in the immediate weeks following bereavement, the mechanism is not well understood. The aim of this study was to determine whether inflammatory and thrombotic changes were present in acute bereavement. Methods and results: Eighty bereaved spouses or parents were prospectively studied within 2 weeks of bereavement (acute) and at 6 months, and compared to 80 non-bereaved participants. Haemostatic measures were obtained between 8 a. m. and 11 a. m. and processed within 1 h. Compared to non-bereaved participants, those acutely bereaved had a higher neutrophil count (4.34 +/- 0.19 vs 3.79 +/- 0.15, p = <0.001), von Willebrand factor antigen (132.33 +/- 3.6 vs 119.95 +/- 3.29, p = 0.02), Factor VIII (1.43 +/- 0.06 vs 1.25 +/- 0.04, p = 0.02) and platelet/granulocyte aggregates (median 383.0 vs 343.5, p = 0.02). Levels of neutrophils, monocytes, eosinophils, platelet count, platelet/monocyte granulocytes and von Willebrand factor were lower in bereaved at 6 months compared to acutely (all p < 0.05). Conclusion: Acute bereavement is associated with inflammatory and prothrombotic changes that may contribute to the increased cardiovascular risk with bereavement and provide clues for future preventative strategies.

引用

页码：1145 / 1152

页数：8

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