The Renin-Angiotensin-Aldosterone System in Podocytes

被引：57

作者：

Wennmann, Dirk Oliver ^{[1
]}

Hsu, Hsiang-Hao ^{[1
,2
,3
]}

Pavenstaedt, Hermann ^{[1
]}

机构：

[1] Univ Hosp Munster, Dept Internal Med D, D-48149 Munster, Germany

[2] Chang Gung Univ, Chang Gung Mem Hosp, Kidney Res Ctr, Tao Yuan, Taiwan

[3] Chang Gung Univ, Chang Gung Mem Hosp, Dept Nephrol, Tao Yuan, Taiwan

来源：

SEMINARS IN NEPHROLOGY | 2012年 / 32卷 / 04期

关键词：

Angiotensin II; aldosterone; prorenin receptor; podocyte; II-RECEPTOR SUBTYPES; (PRO)RENIN RECEPTOR; GLOMERULAR PODOCYTES; DIABETIC-NEPHROPATHY; NEPHRIN EXPRESSION; INTACT GLOMERULUS; PRORENIN RECEPTOR; HYPERTENSIVE-RATS; MOUSE PODOCYTES; ACTIVATION;

D O I：

10.1016/j.semnephrol.2012.06.009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin-aldosterone system (RAAS) plays a critical role in kidney function and its inhibition reduces proteinuria and preserves kidney function in patients with chronic kidney disease. Recent studies have shown that podocytes generate many components of the RAAS and they express receptors of RAAS, including angiotensin II, mineralocorticoid, and prorenin receptors. Crucial functions of podocytes, such as contraction, apoptosis, autophagocytosis, and cytoskeletal organization, have been shown to be regulated by the angiotensin II type 1 receptors. An activation of the glomerular RAAS and protection from podocyte injury by RAAS inhibitors have been shown in many glomerular diseases. Exploring the interaction between the local RAAS and the signaling involved in RAAS activation in podocytes will lead to new therapeutic strategies of podocyte protection.

引用

页码：377 / 384

页数：8

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